Mesoridazine

Mesoridazine Brand Name– Serentil

What is Mesoridazine

NOTE: This drug is discontinued in the US.

Mesoridazine is a phenothiazine antipsychotic agent used for the symptomatic management of psychotic disorders.

Similar to other low potency antipsychotics, mesoridazine has a high incidence of sedation and anticholinergic effects and a low incidence of extrapyramidal reactions. Like its parent compound thioridazine, mesoridazine can produce a variety of adverse cardiovascular effects.

Dose-related effects on ventricular repolarization may lead to QTc interval prolongation. Because of potential cardiovascular risks including torsade de pointes and sudden death, the manufacturer recommends that mesoridazine therapy be reserved for treating schizophrenic patients who have failed to respond to adequate courses of other antipsychotic drugs, either because of inadequate efficacy or intolerable side effects.

Serentil® was approved by the FDA in 1970.

Indications

• behavioral or psychological symptoms of dementia
• schizophrenia

For the treatment of schizophrenia

Side Effects

1. agranulocytosis
2. akathisia
3. anaphylactoid reactions
4. angina
5. angioedema
6. aplastic anemia
7. asphyxia
8. ataxia
9. cardiac arrest
10. cholestasis
11. constipation
12. contact dermatitis
13. corneal opacification
14. dizziness
15. drowsiness
16. dysarthria
17. dystonic reaction
18. ejaculation dysfunction
19. eosinophilia
20. erythema
21. exfoliative dermatitis
22. fever
23. galactorrhea
24. gynecomastia
25. hemolytic anemia
26. hepatitis
27. hyperprolactinemia
28. hyperthermia
29. hyponatremia
30. hypotension
31. hypothermia
32. impotence (erectile dysfunction)
33. jaundice
34. laryngeal edema
35. leukopenia
36. lupus-like symptoms
37. menstrual irregularity
38. miosis
39. nasal congestion
40. nausea
41. neuroleptic malignant syndrome
42. neutropenia
43. pancytopenia
44. photophobia
45. photosensitivity
46. polydipsia
47. priapism
48. pruritus
49. pseudoparkinsonism
50. purpura
51. QT prolongation
52. rash
53. SIADH
54. sinus tachycardia
55. syncope
56. tardive dyskinesia
57. thrombocytopenia
58. torsade de pointes
59. torticollis
60. trismus
61. urinary incontinence
62. urinary retention
63. urticaria
64. vomiting
65. water intoxication
66. weakness
67. xerostomia

Monitoring Parameters

• AIMS assessment
• CBC
• ECG
• ophthalmologic exam
• serum prolactin

Contraindications

• abrupt discontinuation
• agranulocytosis
• alcoholism
• ambient temperature increase
• anticholinergic medications
• bone marrow suppression
• breast cancer
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• chemotherapy
• children
• closed-angle glaucoma
• CNS depression
• coadministration with other CNS depressants
• coma
• coronary artery disease
• dehydration
• dementia
• dental work
• diabetes mellitus
• driving or operating machinery
• dysphagia
• electroconvulsive therapy (ECT)
• electrolyte imbalance
• ethanol ingestion
• females
• fever
• geriatric
• GI obstruction
• head trauma
• hematological disease
• hepatic disease
• hyperprolactinemia
• hyperthermia
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypotension
• hypothermia
• ileus
• infants
• infection
• infertility
• intravenous administration
• jaundice
• labor
• leukopenia
• malnutrition
• neonates
• neurological disease
• neutropenia
• obstetric delivery
• orthostatic hypotension
• Parkinson’s disease
• phenothiazine hypersensitivity
• pregnancy
• pregnancy testing
• prostatic hypertrophy
• QT prolongation
• radiographic contrast administration
• respiratory depression
• Reye’s syndrome
• seizure disorder
• seizures
• strenuous exercise
• stroke
• sunlight (UV) exposure
• surgery
• tardive dyskinesia
• thyroid disease
• tobacco smoking
• torsade de pointes
• urinary retention
• visual impairment
• vomiting

Interactions

• Abarelix
• Acarbose
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetohexamide
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-glucosidase Inhibitors
• Alprazolam
• Amantadine
• Amifampridine
• Amikacin
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Aminolevulinic Acid
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amobarbital
• Amoxapine
• Anxiolytics; Sedatives; and Hypnotics
• Apraclonidine
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atenolol; Chlorthalidone
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzodiazepines
• Bepridil
• Beta-agonists
• Bethanechol
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Phenylephrine
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Cabergoline
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Phenylephrine
• Cariprazine
• Carisoprodol
• Carteolol
• Cenobamate
• Central-acting adrenergic agents
• Cetrorelix
• Charcoal
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloral Hydrate
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorothiazide
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Phenylephrine
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Citalopram
• Class IA Antiarrhythmics
• Clindamycin; Tretinoin
• Clobazam
• Clomipramine
• Clonazepam
• Clorazepate
• Clozapine
• Codeine; Phenylephrine; Promethazine
• COMT inhibitors
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Degarelix
• Desipramine
• Dexmedetomidine
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Quinidine
• Diazepam
• Diethylpropion
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Disopyramide
• Disulfiram
• Dolasetron
• Dolutegravir; Rilpivirine
• Dopamine
• Dorzolamide; Timolol
• Doxepin
• Dronabinol
• Droperidol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Ephedrine
• Epinephrine
• Eprosartan; Hydrochlorothiazide, HCTZ
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Estazolam
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Ethosuximide
• Ethotoin
• Etomidate
• Ezogabine
• Felbamate
• Flecainide
• Flibanserin
• Flucytosine
• Fluocinolone; Hydroquinone; Tretinoin
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurazepam
• Fluvoxamine
• food
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Ganirelix
• Gentamicin
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Goserelin
• Granisetron
• Guaifenesin; Phenylephrine
• Guanidine
• Halobetasol; Tazarotene
• Halofantrine
• Haloperidol
• Halothane
• Hydantoins
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Hydroxyzine
• Ibuprofen; Oxycodone
• Imipramine
• Incretin Mimetics
• Indapamide
• Insulins
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Ipecac
• Isocarboxazid
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Kanamycin
• Ketamine
• Lamotrigine
• Lanthanum Carbonate
• Lemborexant
• Levetiracetam
• Levodopa
• Levomethadyl
• Linagliptin
• Linagliptin; Metformin
• Lomefloxacin
• Lopinavir; Ritonavir
• Lorazepam
• Loxapine
• Magnesium Salts
• Maprotiline
• Meglitinides
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methocarbamol
• Methohexital
• Methoxsalen
• Methsuximide
• Methyclothiazide
• Methylphenidate
• Metoclopramide
• Metolazone
• Metoprolol
• Metyrapone
• Metyrosine
• Midazolam
• Miglitol
• Minocycline
• Mirtazapine
• Mitotane
• Molindone
• Monoamine oxidase inhibitors
• Moxifloxacin
• Nabilone
• Nadolol
• Nafarelin
• Nalbuphine
• Naltrexone
• Nitroglycerin
• Non-Ionic Contrast Media
• Norepinephrine
• Nortriptyline
• Octreotide
• Olanzapine
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Oxazepam
• Oxycodone
• Paliperidone
• Paromomycin
• Paroxetine
• Pazopanib
• Pemoline
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Phenytoin
• Photosensitizing agents (topical)
• Pilocarpine
• Pimozide
• Pindolol
• Pioglitazone
• Plazomicin
• Porfimer
• Pramipexole
• Pramlintide
• Prilocaine; Epinephrine
• Primidone
• Procainamide
• Procarbazine
• Propafenone
• Propoxyphene
• Propranolol
• Protriptyline
• Quazepam
• Quetiapine
• Quinidine
• Ranolazine
• Rasagiline
• Remifentanil
• Rifabutin
• Rifampin
• Rifamycins
• Rifapentine
• Rilpivirine
• Risperidone
• Ropinirole
• Rosiglitazone
• Rotigotine
• Safinamide
• Saquinavir
• Saxagliptin
• Secobarbital
• Segesterone Acetate; Ethinyl Estradiol
• Selegiline
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Simvastatin; Sitagliptin
• Sitagliptin
• Sodium Oxybate
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Sparfloxacin
• St. John’s Wort, Hypericum perforatum
• Streptomycin
• Sufentanil
• Sulfonylureas
• Tacrolimus
• Tazarotene
• Temazepam
• Tetrabenazine
• Thalidomide
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thiothixene
• Tiagabine
• Timolol
• tobacco
• Tobramycin
• Tolazamide
• Tolbutamide
• Topiramate
• Tramadol
• Tranylcypromine
• Trazodone
• Tretinoin, ATRA
• Triazolam
• Tricyclic antidepressants
• Trimethobenzamide
• Trimipramine
• Trospium
• Valproic Acid, Divalproex Sodium
• Vardenafil
• Vemurafenib
• Venlafaxine
• Verteporfin
• Vigabatrin
• Vorinostat
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem
• Zonisamide