Mechlorethamine Nitrogen Mustard Brand Names- Mustargen | VALCHLOR
What is Mechlorethamine Nitrogen Mustard
Mechlorethamine is a bifunctional alkylating chemotherapy agent. Intravenous mechlorethamine is indicated to treat many malignancies including Hodgkin lymphoma, chronic lymphocytic leukemia, chronic myelogenous leukemia, and mycosis fungoides; it has also been used via intracavitary administration to treat malignant pleural effusions.
Mechlorethamine for injection was discontinued by the manufacturer due to extremely low demand of the product in December 2018.
Mechlorethamine topical gel is indicated for the treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma in patients who have received prior skin-directed therapy.
Avoid mechlorethamine exposure to mucous membranes; ocular exposure may result in severe injury or blindness.
Indications
- chronic lymphocytic leukemia (CLL)
- chronic myelogenous leukemia (CML)
- cutaneous T-cell lymphoma (CTCL)
- Hodgkin lymphoma
- lung cancer
- mycosis fungoides
- pericardial effusion
- peritoneal effusion
- pleural effusion
- polycythemia vera
For the treatment of chronic lymphocytic leukemia (CLL)
Side Effects
- agranulocytosis
- alopecia
- amenorrhea
- anaphylactoid reactions
- anemia
- anorexia
- azoospermia
- bleeding
- diarrhea
- erythema multiforme
- exfoliative dermatitis
- GI bleeding
- gonadal suppression
- hearing loss
- hemolytic anemia
- hyperuricemia
- immunosuppression
- infection
- infection
- infertility
- injection site reaction
- jaundice
- leukopenia
- lymphopenia
- maculopapular rash
- nausea
- neutropenia
- new primary malignancy
- oligomenorrhea
- pancytopenia
- petechiae
- phlebitis
- pruritus
- pruritus
- skin hyperpigmentation
- skin ulcer
- spermatogenesis inhibition
- thrombocytopenia
- thrombosis
- tinnitus
- tissue necrosis
- vertigo
- vomiting
- weakness
Monitoring Parameters
- CBC with differential
- serum uric acid
Contraindications
- accidental exposure
- anemia
- bleeding
- bone marrow suppression
- breast-feeding
- children
- contraception requirements
- dental disease
- dental work
- extravasation
- herpes infection
- hyperuricemia
- immunosuppression
- infants
- infection
- infertility
- inflammation
- leukopenia
- male-mediated teratogenicity
- neonates
- neutropenia
- new primary malignancy
- ocular exposure
- pregnancy
- radiation therapy
- reproductive risk
- requires an experienced clinician
- skin disease
- suppurative inflammation
- thrombocytopenia
- tumor lysis syndrome (TLS)
- varicella
- viral infection
Interactions
- Aldesleukin, IL-2
- Amlodipine; Celecoxib
- Celecoxib
- Clozapine
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Echinacea
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Flucytosine
- Flurbiprofen
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Live Vaccines
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Penicillamine
- Piroxicam
- Rofecoxib
- Sulindac
- Tolmetin
- Tuberculin Purified Protein Derivative, PPD
- Valdecoxib
