What is Manganese

Manganese is an essential trace element. In the body, manganese is stored in mitochondria-rich tissues such as the brain, kidney, pancreas, liver, and skeletal muscle parenchyma.

Rich dietary sources include whole grains, cereal products, some vegetables, legumes and nuts.

A role for manganese has been postulated for maintaining strong bones.

There is no established recommended daily allowance (RDA) for manganese. Instead, adequate intakes (AIs) are representative of the dietary needs of various age groups; in healthy infants the AIs describe the mean intake obtainable via breast milk.

Manganese is known to be an important nutrient, but manganese deficiency has not been documented in humans, as dietary intakes often exceed dietary requirements.

Oral dietary supplementation is not normally required. Patients receiving total parenteral nutrition (TPN) require trace element supplementation to prevent deficiency.

Manganese is available in oral dietary nutritional supplements, including some multivitamins, and as a prescription parenteral drug product for intravenous use; the parenteral product is intended for use as an additive to solutions for total parenteral nutrition (TPN).


  • nutritional supplementation

For nutritional supplementation of manganese

for the prophylaxis of manganese deficiency in patients receiving total parenteral nutrition (TPN)

Side Effects

  1. impaired cognition
  2. irritability
  3. tremor

Monitoring Parameters

  • blood manganese


  • biliary obstruction
  • biliary tract disease
  • breast-feeding
  • hepatic disease
  • intramuscular administration
  • pregnancy
  • premature neonates
  • renal failure
  • renal impairment
  • tissue necrosis


There are no drug interactions associated with Manganese products.


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