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Iron Dextran Brand Names- Dexferrum | INFeD
What is Iron Dextran
Iron dextran is used parenterally to treat iron-deficiency anemia. Iron dextran consists of a complex of ferric oxyhydroxide with dextrans of 5000—7000 daltons.
Because fatalities have occurred with the parenteral use, iron dextran is usually reserved for iron-deficient patients unable to take or intolerant to oral iron preparations.
Parenteral iron produces therapeutic responses similar to those of oral iron. One advantage of parenteral iron is that iron stores are rapidly repleted, which may take months to achieve with oral iron therapy.
Iron dextran was approved by the FDA prior to 1982.
Indications
- anemia
- anemia of prematurity
- iron-deficiency anemia
- nutritional supplementation
For the treatment of iron-deficiency anemia in patients in whom oral iron administration is unsatisfactory or impossible
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- arthralgia
- bradycardia
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- chills
- confusion
- cyanosis
- diaphoresis
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- edema
- fever
- flushing
- headache
- hematuria
- hemosiderosis
- hypertension
- hypotension
- injection site reaction
- leukocytosis
- lymphadenopathy
- malaise
- metallic taste
- myalgia
- nausea
- paresthesias
- phlebitis
- pruritus
- pulmonary edema
- purpura
- rash
- respiratory arrest
- seizures
- serious hypersensitivity reactions or anaphylaxis
- skin atrophy
- skin discoloration
- skin necrosis
- syncope
- urticaria
- vomiting
- weakness
- wheezing
Monitoring Parameters
- ferritin
- hemoglobin/hematocrit
- serum iron
- transferrin
Contraindications
- anemia
- ankylosing spondylitis
- asthma
- atopy
- breast-feeding
- cardiac disease
- dialysis
- hemochromatosis
- hemoglobinopathy
- hemosiderosis
- hepatic disease
- hypotension
- infants
- intravenous administration
- iron dextran hypersensitivity
- laboratory test interference
- neonates
- pregnancy
- renal disease
- renal failure
- rheumatoid arthritis
- serious hypersensitivity reactions or anaphylaxis
- systemic lupus erythematosus (SLE)
Interactions
- Amlodipine; Benazepril
- Angiotensin-converting enzyme inhibitors
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Darbepoetin Alfa
- Deferasirox
- Deferiprone
- Deferoxamine
- Dimercaprol
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Epoetin Alfa
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Iron
- Lisinopril
- Methoxy polyethylene glycol-epoetin beta
- Moexipril
- Perindopril
- Perindopril; Amlodipine
- Quinapril
- Ramipril
- Trandolapril
- Trandolapril; Verapamil
- Trientine
