Intranasal Influenza Vaccine Brand Name– FluMist
What is Intranasal Influenza Vaccine
Live attenuated influenza vaccine (LAIV) is a liquid, cold-adapted vaccine containing live-attenuated influenza viruses that are administered as a nasal spray. Intranasal administration stimulates localized mucosal antibody formation, and because the vaccine contains attenuated viruses, an adjuvant to enhance antigen immunogenicity is not needed.
The Advisory Committee on Immunization Practices (ACIP) and the American Academy of Pediatrics (AAP) recommends annual flu vaccination with an age-appropriate influenza vaccine (i.e., inactivated influenza vaccine (IIV), recombinant influenza vaccine (RIV), or quadrivalent LAIV), without preference of 1 product or formulation over another, for everyone 6 months and older.
The LAIV may not be appropriate for patients with immunosuppression.
The IIV is preferred over the LAIV for vaccinating household members, health-care workers, and others who have close contact with severely immunosuppressed persons during periods when such persons require care in a protected environment.
The duration of influenza vaccine virus replication and shedding after intranasal LAIV administration is unknown.
As a precautionary measure, recipients of intranasal LAIV should avoid close contact with severely immunosuppressed persons for 7 days after vaccination
Indications
- seasonal influenza prophylaxis
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- bronchospasm
- chills
- cough
- diarrhea
- fever
- Guillain-Barre syndrome
- headache
- irritability
- lethargy
- meningitis
- myalgia
- nasal congestion
- nausea
- pericarditis
- rash
- rhinorrhea
- sinusitis
- sneezing
- urticaria
- vomiting
- weakness
- wheezing
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- agammaglobulinemia
- aminoglycoside hypersensitivity
- asthma
- breast-feeding
- cardiac disease
- chemotherapy
- children
- chronic lung disease (CLD)
- chronic obstructive pulmonary disease (COPD)
- cystic fibrosis
- diabetes mellitus
- egg hypersensitivity
- fever
- gelatin hypersensitivity
- geriatric
- Guillain-Barre syndrome
- hemoglobinopathy
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hypogammaglobulinemia
- IgA deficiency
- immunosuppression
- infants
- infection
- leukemia
- lymphoma
- multiple sclerosis
- neonates
- neoplastic disease
- neuromuscular disease
- pregnancy
- radiation therapy
- renal failure
- respiratory infection
- Reye’s syndrome
- seizure disorder
- severe combined immunodeficiency (SCID)
- sickle cell disease
Interactions
- Abatacept
- Adalimumab
- Aldesleukin, IL-2
- Alefacept
- Alemtuzumab
- Alkylating agents
- Alpha interferons
- Altretamine
- Amantadine
- Anakinra
- Antimetabolites
- Antithymocyte Globulin
- Antitumor antibiotics
- Axicabtagene Ciloleucel
- Azathioprine
- Baloxavir Marboxil
- Baricitinib
- Basiliximab
- Belatacept
- Belimumab
- Bexarotene
- Blinatumomab
- Brodalumab
- Busulfan
- Canakinumab
- Carmustine, BCNU
- Certolizumab pegol
- Chlorambucil
- Cisplatin
- Clofarabine
- Cortisone
- Cyclophosphamide
- Cyclosporine
- Cytarabine, ARA-C
- Dacarbazine, DTIC
- Daclizumab
- Deflazacort
- Dexamethasone
- Docetaxel
- Dupilumab
- Efalizumab
- Emapalumab
- Estramustine
- Etanercept
- Everolimus
- Fingolimod
- Floxuridine
- Fludrocortisone
- Fluorouracil, 5-FU
- Folate analogs
- Golimumab
- Guselkumab
- Hydrocortisone
- Ifosfamide
- Imatinib
- Inebilizumab
- Infliximab
- Interferon Gamma-1b
- Ixabepilone
- Ixekizumab
- Leflunomide
- Lenalidomide
- Lomustine, CCNU
- Mechlorethamine, Nitrogen Mustard
- Melphalan
- Methylprednisolone
- Mitoxantrone
- Muromonab-CD3
- Mycophenolate
- Natalizumab
- Nelarabine
- Nilotinib
- Obinutuzumab
- Ocrelizumab
- Ofatumumab
- Oseltamivir
- Ozanimod
- Paclitaxel
- Peramivir
- Prednisolone
- Prednisone
- Procarbazine
- Purine analogs
- Rilonacept
- Risankizumab
- Rituximab
- Rituximab; Hyaluronidase
- Sarilumab
- Secukinumab
- Siltuximab
- Siponimod
- Sirolimus
- Streptozocin
- Tacrolimus
- Temozolomide
- Temsirolimus
- Teriflunomide
- Thiotepa
- Tildrakizumab
- Tisagenlecleucel
- Tocilizumab
- Tofacitinib
- Tositumomab
- Triamcinolone
- Ustekinumab
- Vedolizumab
- Venetoclax
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Zanamivir
