Imipenem Cilastatin Relebactam Brand Name– RECARBRIO
What is Imipenem Cilastatin Relebactam
Imipenem cilastatin relebactam is a parenteral combination of a carbapenem antibacterial, a renal dihydropeptidase inhibitor, and a beta-lactamase inhibitor indicated for the treatment of complicated urinary tract infections, including pyelonephritis, and complicated intraabdominal infections in adults who have limited or no alternative treatment options as well as for the treatment of hospital-acquired and ventilator-associated pneumonia in adults.
Imipenem cilastatin relebactam retains activity in the presence of tested efflux pumps and has shown activity against some isolates of P. aeruginosa and Enterobacteriaceae that produce relebactam-susceptible beta-lactamases concomitant with loss of entry porins.
Relebactam protects imipenem from degradation by certain serine beta-lactamases; however, imipenem; cilastatin; relebactam is still not active against most isolates containing metallo-beta-lactamases (MBL) and some oxacillinases with carbapenemase activity.
Seizures have been reported with imipenem; cilastatin, especially when the recommended dosage is exceeded and most commonly in patients with central nervous system (CNS) disorders and/or impaired renal function.
Indications
- Acinetobacter baumannii
- Acinetobacter calcoaceticus
- Bacteroides caccae
- Bacteroides fragilis
- Bacteroides ovatus
- Bacteroides stercoris
- Bacteroides thetaiotaomicron
- Bacteroides uniformis
- Bacteroides vulgatus
- Citrobacter freundii
- Citrobacter koseri
- Eggerthella lenta
- Enterobacter asburiae
- Enterobacter cloacae
- Enterococcus faecalis
- Escherichia coli
- Fusobacterium necrophorum
- Fusobacterium nucleatum
- Fusobacterium varium
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- nosocomial pneumonia
- Parabacteroides distasonis
- Parabacteroides goldsteinii
- Parabacteroides merdae
- Parvimonas micra
- Peptoniphilus harei
- Peptostreptococcus anaerobius
- pneumonia
- Prevotella bivia
- Pseudomonas aeruginosa
- pyelonephritis
- Serratia marcescens
- Staphylococcus aureus (MSSA)
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus pneumoniae
- urinary tract infection (UTI)
- Veillonella parvula
Side Effects
- agitation
- agranulocytosis
- anaphylactoid reactions
- anemia
- confusion
- constipation
- delirium
- diarrhea
- drowsiness
- elevated hepatic enzymes
- erythema
- fever
- headache
- hemolytic anemia
- hepatic failure
- hypertension
- hypokalemia
- hyponatremia
- injection site reaction
- jaundice
- myoclonia
- nausea
- phlebitis
- pseudomembranous colitis
- rash
- seizures
- superinfection
- thrombocytopenia
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- diarrhea
- geriatric
- head trauma
- laboratory test interference
- neurological disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- seizure disorder
- seizures
Interactions
- Colchicine; Probenecid
- Disulfiram
- Ganciclovir
- Oral Contraceptives
- Probenecid
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Theophylline, Aminophylline
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Warfarin
