Hemin (hematin)

Hemin Brand Name– Panhematin

What is Hemin (hematin)

Hemin (also known as hematin) is an enzyme inhibitor used for the treatment of acute intermittent porphyria (AIP). Hemin is an iron containing metalloporphyrin made from processed red blood cells.

The drug is indicated for amelioration of recurrent attacks of AIP related to the menstrual cycle in susceptible women.

It helps to control manifestations of AIP such as hypertension, pain, tachycardia, abnormal mental status, and mild to progressive neurologic signs.

Hemin has also showed similar effects in other patients with AIP, porphyria variegata, and hereditary coproporphyria.

However, hemin is not indicated for patients with porphyria cutanea tarda.

Hemin was approved by the FDA July 20, 1983 and was subsequently designated an orphan drug March 16, 1984.

Indications

  • acute intermittent porphyria

For the treatment of recurrent attacks of acute intermittent porphyria related to the menstrual cycle or other patients† with acute intermittent porphyria, porphyria variegata†, or hereditary coproporphyria

Side Effects

  1. azotemia
  2. coagulopathy
  3. fever
  4. infection
  5. leukocytosis
  6. oliguria
  7. phlebitis
  8. thrombocytopenia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticoagulant therapy
  • breast-feeding
  • infection
  • intramuscular administration
  • latex hypersensitivity
  • preeclampsia
  • pregnancy
  • requires an experienced clinician
  • subcutaneous administration
  • viral infection

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Amobarbital
  • Anticoagulants
  • Antithrombin III
  • Apixaban
  • Argatroban
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betrixaban
  • Bivalirudin
  • Butabarbital
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticosteroids
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Edoxaban
  • Elagolix; Estradiol; Norethindrone acetate
  • Enoxaparin
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Fondaparinux
  • Heparin
  • Lepirudin
  • Mephobarbital
  • Mestranol; Norethindrone
  • Methohexital
  • Pentobarbital
  • Pentosan
  • Phenobarbital
  • Primidone
  • Rivaroxaban
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Thiopental
  • Tinzaparin
  • Warfarin
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