Glecaprevir Pibrentasvir Brand Name– Mavyret
What is Glecaprevir Pibrentasvir
Glecaprevir pibrentasvir is an oral fixed-dose combination of glecaprevir, a hepatitis C virus (HCV) NS3/4A protease inhibitor, and pibrentasvir, an HCV NS5A inhibitor.
The drug is approved to treat chronic HCV genotypes 1, 2, 3, 4, 5, and 6 infections in adults and pediatric patients (12 years and older or weighing at least 45 kg) who are without cirrhosis or have compensated cirrhosis (Child-Pugh A).
For all HCV genotypes, the drug may be given to treatment-naive patients and to patients who previously received an antiviral regimen containing an interferon, ribavirin, and/or sofosbuvir.
The drug is also indicated to treat patients with HCV genotype 1 infection who were previously treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both.
For treatment-naive patients, the duration of therapy is 8 weeks; however, the duration in treatment-experienced patients ranges from 8 to 16 weeks based on genotype and previous treatment history.
Glecaprevir pibrentasvir is contraindicated for use in patients with moderate to severe hepatic impairment (Child-Pugh B or C) and in those with any history of prior hepatic decompensation.
Indications
- hepatitis C infection
- hepatitis C virus
Side Effects
- angioedema
- asthenia
- diarrhea
- fatigue
- headache
- hepatic decompensation
- hepatic failure
- hepatitis B exacerbation
- hyperbilirubinemia
- jaundice
- nausea
- pruritus
Monitoring Parameters
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
Contraindications
- alcoholism
- anticoagulant therapy
- ascites
- breast-feeding
- diabetes mellitus
- hepatic decompensation
- hepatic disease
- hepatic encephalopathy
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatocellular cancer
- hyperglycemia
- hypoglycemia
- jaundice
- pregnancy
Interactions
- Acalabrutinib
- Acarbose
- Acetohexamide
- Afatinib
- Albiglutide
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpelisib
- Amiodarone
- Amlodipine; Atorvastatin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antidiabetic Agents
- Apalutamide
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betrixaban
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bosentan
- Brigatinib
- Budesonide
- Budesonide; Formoterol
- Cabozantinib
- Canagliflozin
- Canagliflozin; Metformin
- Capmatinib
- Carbamazepine
- Carvedilol
- Cenobamate
- Chlorpropamide
- Clarithromycin
- Cobicistat
- Cobimetinib
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Dabigatran
- Daclatasvir
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Daunorubicin Liposomal
- Daunorubicin Liposomal; Cytarabine Liposomal
- Dexamethasone
- Dextromethorphan; Quinidine
- Digoxin
- Docetaxel
- Doxorubicin
- Doxorubicin Liposomal
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Tenofovir alafenamide
- Enzalutamide
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etravirine
- Exenatide
- Ezetimibe; Simvastatin
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Fluticasone; Umeclidinium; Vilanterol
- Fluvastatin
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Fostemsavir
- Gemfibrozil
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Imatinib
- Indinavir
- Insulin Aspart
- Insulin Aspart; Insulin Aspart Protamine
- Insulin Degludec; Liraglutide
- Insulin Detemir
- Insulin Glargine
- Insulin Glargine; Lixisenatide
- Insulin Glulisine
- Insulin Lispro
- Insulin Lispro; Insulin Lispro Protamine
- Insulin, Inhaled
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isophane Insulin (NPH)
- Itraconazole
- Ivacaftor
- Ketoconazole
- Lapatinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Lente Insulin
- Letermovir
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Maraviroc
- Mefloquine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methotrexate
- Mifepristone
- Miglitol
- Mitotane
- Mitoxantrone
- Morphine
- Morphine; Naltrexone
- Naldemedine
- Nateglinide
- Nelfinavir
- Neratinib
- Niacin; Simvastatin
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Osimertinib
- Ozanimod
- Paclitaxel
- Panobinostat
- Pazopanib
- Pexidartinib
- Phenobarbital
- Phenytoin
- Pioglitazone
- Pitavastatin
- Posaconazole
- Pramlintide
- Pravastatin
- Prednisone
- Primidone
- Propafenone
- Quinidine
- Quinine
- Ranolazine
- Regorafenib
- Regular Insulin
- Regular Insulin; Isophane Insulin (NPH)
- Repaglinide
- Revefenacin
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rimegepant
- Risperidone
- Ritonavir
- Romidepsin
- Rosiglitazone
- Rosuvastatin
- Sacituzumab Govitecan
- Sapropterin
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Semaglutide
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Sitagliptin
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sorafenib
- St. John’s Wort, Hypericum perforatum
- Sulfasalazine
- Tafamidis
- Talazoparib
- Tamoxifen
- Telithromycin
- Temsirolimus
- Teniposide
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Teriflunomide
- Tezacaftor; Ivacaftor
- Ticagrelor
- Tipranavir
- Tolazamide
- Tolbutamide
- Tolvaptan
- Topotecan
- Trandolapril; Verapamil
- Tucatinib
- Ubrogepant
- Ultralente Insulin
- Umeclidinium
- Umeclidinium; Vilanterol
- Venetoclax
- Verapamil
- Vinblastine
- Vincristine
- Vincristine Liposomal
- Warfarin
- Zonisamide
