Fidaxomicin Brand Name– DIFICID
What is Fidaxomicin
Fidaxomicin is an oral macrolide antibiotic used to treat Clostridium difficile-associated diarrhea (CDAD) in adults and pediatric patients 6 months and older. It is bactericidal against C. difficile, including hypervirulent strains.
Fidaxomicin may have an increased sustained response as compared to oral vancomycin. Systemic absorption of fidaxomicin is minimal.
Indications
- Clostridium difficile
- pseudomembranous colitis
Side Effects
- abdominal pain
- anemia
- angioedema
- constipation
- diarrhea
- dyspepsia
- dysphagia
- dyspnea
- elevated hepatic enzymes
- fever
- flatulence
- GI bleeding
- GI obstruction
- hyperglycemia
- metabolic acidosis
- nausea
- neutropenia
- pruritus
- rash
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- stool exam
Contraindications
- breast-feeding
- geriatric
- macrolide hypersensitivity
- pregnancy
Interactions
- Cyclosporine
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Segesterone Acetate; Ethinyl Estradiol
