Fexofenadine

Fexofenadine Brand Names

Allegra | Allegra Allergy 12 Hour | Allegra Allergy 24 Hour | Allegra Children’s Allergy | Allegra Children’s Allergy ODT | Allegra ODT | Allergy Relief | Children’s Allergy Fexofenadine

What is Fexofenadine

Fexofenadine is a non-sedating antihistamine (H1-receptor antagonist). It is the active metabolite of another H1-antagonist, terfenadine.

Unlike terfenadine, fexofenadine does not generally cause QT prolongation when given in doses up to 800 mg/day or when administered concomitantly with ketoconazole or erythromycin.

However, one case report documented ventricular tachycardia associated with QT prolongation during fexofenadine therapy in a patient with a history of prolonged QT interval.

Fexofenadine (Allegra) was first FDA approved in July 1996 for the treatment of seasonal allergic rhinitis; subsequent approval was granted in February 2000 for a once-daily product and for the treatment of chronic idiopathic urticaria.

Other formulations were similarly approved including an oral liquid in October 2006 and an orally disintegrating tablet in July 2007.

In January 2011, the FDA approved the over-the-counter sale of fexofenadine in the same formulations, strengths, and indications as available by prescription, with the exception that treatment of urticaria in certain pediatric patients

Indications

1. allergic rhinitis
2. chronic idiopathic urticaria
3. perennial allergies
4. seasonal allergies

For the management of symptoms of perennial allergies and seasonal allergies, including allergic rhinitis

Side Effects

1. anaphylactoid reactions
2. angioedema
3. back pain
4. chest pain (unspecified)
5. cough
6. diarrhea
7. dizziness
8. dysmenorrhea
9. dyspepsia
10. dyspnea
11. fatigue
12. fever
13. flushing
14. headache
15. infection
16. insomnia
17. myalgia
18. paranoia
19. pharyngitis
20. pruritus
21. rash
22. restlessness
23. rhinorrhea
24. urticaria
25. vomiting

Monitoring Parameters

• serum creatinine/BUN

Contraindications

• breast-feeding
• children
• driving or operating machinery
• geriatric
• infants
• neonates
• phenylketonuria
• pregnancy
• renal disease
• renal failure
• renal impairment
• terfenadine hypersensitivity

Interactions

• Alogliptin; Pioglitazone
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Antacids
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Atazanavir; Cobicistat
• Boceprevir
• Cabozantinib
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Carvedilol
• Cobicistat
• Conivaptan
• Daclatasvir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Desloratadine
• Desloratadine; Pseudoephedrine
• Elexacaftor; tezacaftor; ivacaftor
• Eltrombopag
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Etravirine
• Fosamprenavir
• Fostamatinib
• Glecaprevir; Pibrentasvir
• Glimepiride; Pioglitazone
• grapefruit juice
• Heparin
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Ixabepilone
• Ketoconazole
• Ledipasvir; Sofosbuvir
• Lomitapide
• Lopinavir; Ritonavir
• Loratadine
• Loratadine; Pseudoephedrine
• Lumacaftor; Ivacaftor
• Magnesium Hydroxide
• Metformin; Pioglitazone
• Neratinib
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Sodium Bicarbonate
• Pioglitazone
• Ponatinib
• Posaconazole
• Rifampin
• Ritonavir
• Sapropterin
• Sincalide
• Sodium Bicarbonate
• Sofosbuvir; Velpatasvir; Voxilaprevir
• St. John’s Wort, Hypericum perforatum
• Telaprevir
• Telithromycin
• Ulipristal
• Vemurafenib