Ferumoxytol Brand Name– Feraheme
What is Ferumoxytol
Ferumoxytol is an intravenous iron replacement product indicated for the treatment of iron deficiency anemia in adults with chronic kidney disease.
Compared to oral iron (200 mg/day for 21 days) in patients with chronic kidney disease and iron deficiency anemia, ferumoxytol use produced a significantly higher increase in hemoglobin over baseline at 35 days.
Ferumoxytol was well tolerated; however, fatal and serious hypersensitivity reactions have been reported with ferumoxytol, and patients should be monitored for at least 30 minutes after ferumoxytol administration
Indications
- iron-deficiency anemia
- magnetic resonance imaging (MRI)
For the treatment of iron-deficiency anemia in patients with chronic kidney disease or intolerance or unsatisfactory response to oral iron
Side Effects
- abdominal pain
- angioedema
- back pain
- chest pain (unspecified)
- constipation
- cough
- cyanosis
- diarrhea
- dizziness
- dyspnea
- edema
- fever
- headache
- hypertension
- hypotension
- muscle cramps
- nausea
- peripheral edema
- pruritus
- rash
- serious hypersensitivity reactions or anaphylaxis
- sinus tachycardia
- syncope
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- ferritin
- hemoglobin/hematocrit
- serum iron
- transferrin
Contraindications
- breast-feeding
- dialysis
- geriatric
- hemochromatosis
- hemoglobinopathy
- hemosiderosis
- hepatic disease
- hypotension
- laboratory test interference
- magnetic resonance imaging (MRI)
- pregnancy
- requires a specialized care setting
- serious hypersensitivity reactions or anaphylaxis
Interactions
- Darbepoetin Alfa
- Deferasirox
- Deferiprone
- Deferoxamine
- Dimercaprol
- Epoetin Alfa
- Iron
- Methoxy polyethylene glycol-epoetin beta
