Famotidine

Famotidine Brand Names- Heartburn Relief | Pepcid | Pepcid AC | Pepcid AC Maximum Strength

What is Famotidine

Famotidine is an oral and parenteral histamine type 2-receptor antagonist (H2RA) used in the treatment of gastrointestinal disorders such as peptic ulcer and gastroesophageal reflux disease (GERD).

The actions and indications of famotidine differ little from the other agents in the same class, except that famotidine is less likely than cimetidine to interact with other drugs.

 Over-the-counter oral formulations are available for the prophylaxis and treatment of heartburn and acid indigestion in adolescent and adult patients.

H2RAs are often used for stress ulcer prophylaxis in critically ill patients; however, evidence for benefit is lacking, and use may increase the risk of adverse reactions such as pneumonia and Clostridioides difficile infection.

Reserve stress ulcer prophylaxis for patients with risk factors for clinically significant gastrointestinal bleeding (e.g., multiple organ dysfunction, prolonged mechanical ventilation, coagulopathy, persistent shock, concomitant corticosteroid therapy).

Indications

1. aspiration prophylaxis
2. duodenal ulcer
3. dyspepsia
4. esophagitis
5. gastric ulcer
6. gastroesophageal reflux disease (GERD)
7. multiple endocrine adenoma syndrome
8. NSAID-induced ulcer prophylaxis
9. pyrosis (heartburn)
10. stress gastritis prophylaxis
11. systemic mastocytosis
12. Zollinger-Ellison syndrome

For self-medication of pyrosis (heartburn), acid dyspepsia (acid indigestion), or sour stomach, either for prophylaxis or for symptomatic relief

Side Effects

1. acne vulgaris
2. agitation
3. agranulocytosis
4. alopecia
5. anaphylactoid reactions
6. angioedema
7. anorexia
8. anxiety
9. arrhythmia exacerbation
10. arthralgia
11. asthenia
12. atrophic gastritis
13. AV block
14. bronchospasm
15. cholestasis
16. confusion
17. conjunctivitis
18. constipation
19. delirium
20. depression
21. diarrhea
22. dizziness
23. drowsiness
24. dysgeusia
25. edema
26. fatigue
27. fever
28. flushing
29. gynecomastia
30. hallucinations
31. headache
32. hepatitis
33. impotence (erectile dysfunction)
34. infection
35. insomnia
36. jaundice
37. lethargy
38. leukopenia
39. libido decrease
40. muscle cramps
41. musculoskeletal pain
42. nausea
43. palpitations
44. pancytopenia
45. paranoia
46. paresthesias
47. pernicious anemia
48. pruritus
49. QT prolongation
50. rash
51. rhabdomyolysis
52. seizures
53. Stevens-Johnson syndrome
54. thrombocytopenia
55. tinnitus
56. toxic epidermal necrolysis
57. urticaria
58. vitamin B12 deficiency
59. vomiting
60. xerosis
61. xerostomia

Monitoring Parameters

• intragastric pH
• serum creatinine/BUN

Contraindications

• breast-feeding
• children
• gastric cancer
• geriatric
• GI bleeding
• H2-blocker hypersensitivity
• hepatic disease
• infants
• infection
• neonates
• phenylketonuria
• pregnancy
• QT prolongation
• renal disease
• renal failure
• renal impairment
• tobacco smoking
• vitamin B12 deficiency

Interactions

• Acalabrutinib
• Alendronate
• Alendronate; Cholecalciferol
• Alogliptin; Metformin
• Amphetamine; Dextroamphetamine Salts
• Aripiprazole
• Atazanavir
• Atazanavir; Cobicistat
• Bisacodyl
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bosutinib
• Budesonide
• Budesonide; Formoterol
• Bupivacaine; Lidocaine
• Calcium Carbonate; Risedronate
• Canagliflozin; Metformin
• Cefditoren
• Cefpodoxime
• Ceftibuten
• Cefuroxime
• Cysteamine
• Dacomitinib
• Dapagliflozin; Metformin
• Dasatinib
• Delavirdine
• Dexmethylphenidate
• Dichlorphenamide
• Diphenhydramine; Naproxen
• Dirithromycin
• Dolutegravir; Rilpivirine
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Erlotinib
• Ertugliflozin; Metformin
• Esomeprazole; Naproxen
• Ethanol
• Fosamprenavir
• Gefitinib
• Glipizide; Metformin
• Glyburide; Metformin
• Iron
• Itraconazole
• Ketoconazole
• Lansoprazole; Naproxen
• Ledipasvir; Sofosbuvir
• Lidocaine
• Lidocaine; Prilocaine
• Linagliptin; Metformin
• Mefloquine
• Mesalamine, 5-ASA
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methylphenidate
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Neratinib
• Nilotinib
• Pazopanib
• Pexidartinib
• Polyethylene Glycol; Electrolytes; Bisacodyl
• Ponatinib
• Rasagiline
• Rilpivirine
• Risedronate
• Secretin
• Selpercatinib
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Sonidegib
• Thalidomide
• Theophylline, Aminophylline
• Tizanidine