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Factor 9 Brand Names
AlphaNine SD | ALPROLIX | Bebulin | Bebulin VH | BeneFIX | IDELVION | IXINITY | Mononine | Profilnine | Profilnine SD | Proplex T | REBINYN | RIXUBIS
What is Factor 9
Factor 9 is a coagulation factor used for prophylactic and on-demand treatment of hemophilia B.
Both plasma-derived and recombinant concentrates are suitable for hemophilia B management; however, due to their better safety profile, recombinant factor IX products are often the first choice of treatment in industrialized countries.
Despite the improved safety of plasma-derived products (e.g., screening plasma donors, testing for viral presence, viral inactivation and/or reduction), concerns regarding the transmission of prions, nonencapsulated viruses, and other unknown pathogens still exist. In addition, products containing only factor IX are preferable to complex concentrates which also contain factors II, VII, and X; products containing activated clotting factors may increase the risk of thromboembolism.
The development of factor IX products with prolonged half-lives improves patient adherence by enabling less frequent infusions, decreasing the bleeding rate, and reducing the burden of treatment.
Several technologies have been applied to extend the half-life of factor IX, including the addition of polyethylene glycol (PEG) and the fusion of albumin or the fragment crystallizable (Fc) domain of human IgG to factor 9.
Indications
- bleeding prophylaxis
- hemophilia B
- hemorrhage
- surgical bleeding
For the prevention and control of hemorrhage in patients with hemophilia B (congenital factor IX deficiency or Christmas disease)
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- antibody formation
- asthenia
- blurred vision
- chills
- cough
- cyanosis
- depression
- diaphoresis
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- erythema
- fatigue
- fever
- flushing
- halitosis
- headache
- hematuria
- hepatitis
- hypotension
- hypoxia
- infection
- influenza
- injection site reaction
- lethargy
- myocardial infarction
- nausea
- nephrotic syndrome
- palpitations
- paresthesias
- phlebitis
- pruritus
- pulmonary embolism
- rash
- restlessness
- stroke
- thrombosis
- tremor
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- clotting inhibitor titers
- factor IX concentrations
Contraindications
- breast-feeding
- children
- coronary artery disease
- disseminated intravascular coagulation (DIC)
- factor IX inhibitors
- fibrinolysis
- hamster protein hypersensitivity
- hepatic disease
- hepatitis
- human immunodeficiency virus (HIV) infection
- infants
- infection
- mannitol hypersensitivity
- murine protein hypersensitivity
- neonates
- pregnancy
- sucrose hypersensitivity
- surgery
- thromboembolic disease
Interactions
- Aminocaproic Acid
- Factor VIIa, Recombinant
- Tranexamic Acid
