Factor 13 A Subunit Recombinant Brand Name– TRETTEN
What is Factor 13 A Subunit Recombinant
Factor 13 A Subunit Recombinant is used for the routine prophylaxis of bleeding in patients with congenital factor XIII A-subunit deficiency.
Factor XIII is the terminal enzyme in the blood coagulation cascade and is composed of 2 factor XIII A-subunits and 2 factor XIII B-subunits. The enzymatic activity resides in factor XIII A-subunits.
Recombinant factor XIII A-subunit is manufactured as an intracellular, soluble protein in yeast cells. No human or animal products are involved in the manufacturing process of recombinant factor XIII A-subunit.
Factor 13 A Subunit Recombinant was approved by the FDA in December 2013
Indications
- bleeding prophylaxis
For routine bleeding prophylaxis in patients with congenital factor XIII A-subunit deficiency
Side Effects
- antibody formation
- headache
Monitoring Parameters
- clotting inhibitor titers
- factor XIII concentrations
Contraindications
- breast-feeding
- factor XIII inhibitors
- pregnancy
- thromboembolic disease
Interactions
- Factor 7a, Recombinant
