Etidocaine

Etidocaine Brand Name

What is Etidocaine

NOTE: This drug is discontinued in the US.

Etidocaine is a long-acting local anesthetic of the amide type. It is used for epidural, local, and retrobulbar anesthesia in surgical and dental procedures.

Like lidocaine, it has a rapid onset of sensory and motor blockade, but duration of analgesia is 1.5—2 times longer than lidocaine when given peridurally.

This difference is greater following peripheral nerve block, when duration of analgesia in excess of 9 hours is common.

Etidocaine produces profound motor blockade and muscle relaxation when used for peridural analgesia.

Etidocaine is available as parenteral injection with or without epinephrine. It received FDA approval in 1976.

Etidocaine products, with or without epinephrine, were removed from the US market in 2001.

Indications

  1. Caesarean section anesthesia
  2. central neural block
  3. epidural anesthesia
  4. inferior alveolar nerve block
  5. infiltration anesthesia
  6. intraabdominal anesthesia
  7. local anesthesia
  8. lower limb anesthesia
  9. maxillary nerve block
  10. ophthalmic anesthesia
  11. pelvic anesthesia
  12. peripheral nerve block
  13. regional anesthesia
  14. retrobulbar nerve block

Side Effects

  1. anaphylactoid reactions
  2. angina
  3. anxiety
  4. atrial fibrillation
  5. AV block
  6. back pain
  7. bradycardia
  8. cardiac arrest
  9. decreased uterine contractility
  10. dizziness
  11. drowsiness
  12. fetal acidosis
  13. fetal bradycardia
  14. headache
  15. hypotension
  16. injection site reaction
  17. nausea
  18. neonatal depression
  19. palpitations
  20. PR prolongation
  21. pruritus
  22. QT prolongation
  23. rash
  24. respiratory depression
  25. restlessness
  26. seizures
  27. shivering
  28. tremor
  29. trismus
  30. urticaria
  31. visual impairment
  32. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • amide local anesthetic hypersensitivity
  • anticoagulant therapy
  • AV block
  • breast-feeding
  • cardiac disease
  • children
  • coagulopathy
  • dehydration
  • eclampsia
  • fetal distress
  • fetal prematurity
  • geriatric
  • head and neck anesthesia
  • heart failure
  • hepatic disease
  • hypertension
  • hypotension
  • hypovolemia
  • infection
  • intraarterial administration
  • intrathecal administration
  • intravenous administration
  • labor
  • myasthenia gravis
  • neurological disease
  • obstetric delivery
  • ocular surgery
  • paracervical nerve block
  • pregnancy
  • pudendal nerve block
  • QT prolongation
  • sepsis
  • shock
  • thrombocytopenia

Interactions

No information is available regarding drug interactions associated with Etidocaine

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