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What is Estrone
NOTE: These products are discontinued in the U.S.
Estrone is a naturally occurring steroidal estrogen that is one-third less active at the cellular level than estradiol, the principal premenopausal human estrogen.
Estrone is obtained from pregnant equine urine or prepared synthetically. Most commercially available estrone products are synthesized.
There is no evidence that ‘natural’ estrogens are more or less efficacious or safe than ‘synthetic’ estrogens.
Estrone is used primarily to treat vasomotor and urogenital symptoms associated with menopause, and for the prevention of osteoporosis. Estrone has also been used for conditions related to gonadotropin hormone dysfunction.
While many estrogen products were marketed as early as 1938, estrone injections were first FDA-approved in 1979 but have not been commercially marketed in the U.S. for decades.
Estrone is available in bulk products that are sometimes used for compounding estrogen products for specific patient needs.
The North American Menopause Society (NAMS) notes that compounded hormonal therapy can present safety concerns such as minimal government regulation and monitoring, dosing issues, the presence of impurities or lack of sterility, lack of scientific efficacy and safety data, and lack of a label outlining risks.
Prescribers using compounded products are encouraged to document the medical choice of compounded hormones over commercially available FDA-approved therapies
Indications
- atrophic vaginitis
- breast cancer
- dysfunctional uterine bleeding
- hot flashes
- hypogonadism
- menopause
- oophorectomy
- ovarian failure
- prostate cancer
For treatment of moderate to severe vasomotor symptoms (hot flashes) of menopause and/or related genitourinary symptoms including atrophic vaginitis, vulvar atrophy (kraurosis vulvae), whether menopause is natural or surgical (e.g., due to oophorectomy)
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- amenorrhea
- anorexia
- anxiety
- biliary obstruction
- breakthrough bleeding
- breast discharge
- breast enlargement
- candidiasis
- cervical dysplasia
- cervicitis
- cholecystitis
- cholelithiasis
- cholestasis
- depression
- diarrhea
- diplopia
- dizziness
- dysmenorrhea
- edema
- elevated hepatic enzymes
- emotional lability
- endometrial hyperplasia
- erythema
- erythema nodosum
- fatigue
- fluid retention
- galactorrhea
- gingivitis
- gynecomastia
- headache
- hepatitis
- hepatoma
- hyperglycemia
- hypertension
- hypocalcemia
- impaired cognition
- injection site reaction
- insomnia
- jaundice
- keratoconus
- libido decrease
- libido increase
- maculopapular rash
- mastalgia
- melasma
- menorrhagia
- migraine
- myocardial infarction
- nausea
- optic neuritis
- pancreatitis
- peliosis hepatis
- pruritus
- pulmonary embolism
- retinal thrombosis
- secondary malignancy
- stroke
- teratogenesis
- thromboembolism
- thrombosis
- urinary incontinence
- urticaria
- vaginal bleeding
- vaginitis
- vomiting
- weight gain
Monitoring Parameters
- pap smear
- pelvic exam
Contraindications
- asthma
- benzyl alcohol hypersensitivity
- breast cancer
- breast-feeding
- cardiac disease
- cerebrovascular disease
- cervical cancer
- children
- contact lenses
- coronary artery disease
- dementia
- depression
- diabetes mellitus
- endometrial cancer
- endometrial hyperplasia
- endometriosis
- gallbladder disease
- geriatric
- hepatic disease
- hepatocellular cancer
- hypercalcemia
- hypercholesterolemia
- hyperlipoproteinemia
- hypertension
- hypocalcemia
- hypoparathyroidism
- hypothyroidism
- intravenous administration
- jaundice
- migraine
- myocardial infarction
- neonates
- new primary malignancy
- obesity
- ovarian cancer
- pancreatitis
- paraben hypersensitivity
- porphyria
- pregnancy
- protein C deficiency
- protein S deficiency
- renal disease
- seizure disorder
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thromboembolism
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine cancer
- uterine leiomyomata
- vaginal bleeding
- vaginal cancer
- visual disturbance
Interactions
No information is available regarding drug interactions associated with Estrone
