Estradiol Progesterone Brand Name– Bijuva
What is Estradiol Progesterone
Estradiol and progesterone are used together in an oral preparation for hormone replacement therapy in women with an intact uterus to treat moderate to severe vasomotor symptoms associated with menopause.
Estradiol is the principal intracellular human estrogen and is substantially more active than its metabolites, estrone and estriol, at the cellular level.
Like other estrogens, estradiol also improves genitourinary symptoms associated with menopause.
Progesterone is a naturally occurring progestin. In the female human body, progesterone is synthesized in the ovaries, placenta, and the adrenal cortex. The addition of a progestin to the estrogen replacement therapy substantially reduces, but does not eliminate, the risk for endometrial hyperplasia.
However, combination HRT may add additional health risks for some women, and hormone replacement regimens are recommended to be used for the shortest duration consistent with the treatment goals of the individual patients.
An estradiol progesterone oral combination product was FDA-approved in October 2018
Indications
- atrophic vaginitis
- hot flashes
- menopause
- oophorectomy
For treatment of moderate to severe vasomotor symptoms (hot flashes) of menopause and/or related genitourinary symptoms including atrophic vaginitis, vulvar atrophy (kraurosis vulvae), whether menopause is natural or surgical (e.g., due to oophorectomy)
Side Effects
- abdominal pain
- acne vulgaris
- alopecia
- amenorrhea
- anxiety
- biliary obstruction
- bowel ischemia
- breakthrough bleeding
- breast cancer
- breast discharge
- breast enlargement
- candidiasis
- cervical dysplasia
- cervicitis
- cholecystitis
- cholestasis
- colitis
- dementia
- depression
- diplopia
- dysmenorrhea
- edema
- elevated hepatic enzymes
- emotional lability
- endometrial cancer
- endometrial hyperplasia
- erythema multiforme
- erythema nodosum
- fatigue
- fluid retention
- galactorrhea
- headache
- hepatitis
- hirsutism
- hypercalcemia
- hyperglycemia
- hypertension
- hypertriglyceridemia
- hypocalcemia
- hypothyroidism
- impaired cognition
- insomnia
- irritability
- jaundice
- leukorrhea
- libido decrease
- libido increase
- mastalgia
- melasma
- migraine
- myocardial infarction
- nausea
- new primary malignancy
- ovarian cancer
- pancreatitis
- papilledema
- peliosis hepatis
- pelvic pain
- peripheral edema
- pruritus
- pulmonary embolism
- rash
- retinal thrombosis
- stroke
- teratogenesis
- thromboembolism
- thrombosis
- urinary incontinence
- urticaria
- vaginal bleeding
- vaginitis
- visual impairment
- vomiting
- weight gain
Monitoring Parameters
- pap smear
- pelvic exam
Contraindications
- angioedema
- asthma
- breast cancer
- breast-feeding
- cardiac disease
- cerebrovascular disease
- cervical cancer
- children
- contact lenses
- coronary artery disease
- dementia
- depression
- diabetes mellitus
- endometrial cancer
- endometrial hyperplasia
- endometriosis
- gallbladder disease
- geriatric
- hepatic disease
- hepatocellular cancer
- history of angioedema
- hypercalcemia
- hypercholesterolemia
- hypertension
- hypertriglyceridemia
- hypocalcemia
- hypoparathyroidism
- hypothyroidism
- infants
- jaundice
- migraine
- myocardial infarction
- new primary malignancy
- obesity
- ovarian cancer
- pancreatitis
- porphyria
- pregnancy
- protein C deficiency
- protein S deficiency
- renal disease
- seizure disorder
- stroke
- surgery
- systemic lupus erythematosus (SLE)
- thromboembolic disease
- thromboembolism
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine cancer
- uterine leiomyomata
- vaginal bleeding
- vaginal cancer
- visual disturbance
Interactions
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Propoxyphene
- Acetohexamide
- Albiglutide
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anastrozole
- Apalutamide
- Aprepitant, Fosaprepitant
- Armodafinil
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betamethasone
- Bexarotene
- Bosentan
- Brigatinib
- Bromocriptine
- Budesonide
- Budesonide; Formoterol
- Butabarbital
- Calcium
- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
- Cenobamate
- Chenodiol
- Chloramphenicol
- Chlorpropamide
- Ciclesonide
- Cimetidine
- Clarithromycin
- Clobazam
- Cobicistat
- Conivaptan
- Corticosteroids
- Cortisone
- Cosyntropin
- Cyclosporine
- Danazol
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daratumumab; Hyaluronidase
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Dexamethasone
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Doxorubicin
- Dulaglutide
- Duloxetine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enzalutamide
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethotoin
- Exemestane
- Exenatide
- Felbamate
- Fluconazole
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- food
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- grapefruit juice
- Griseofulvin
- Hemin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocortisone
- Icosapent ethyl
- Imatinib
- Incretin Mimetics
- Indinavir
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lenalidomide
- Lesinurad
- Lesinurad; Allopurinol
- Letrozole
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin
- Linagliptin; Metformin
- Liothyronine
- Liraglutide
- Lixisenatide
- Lopinavir; Ritonavir
- Lorlatinib
- Meglitinides
- Melatonin
- Mephobarbital
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methohexital
- Methylprednisolone
- Metreleptin
- Metyrapone
- Midazolam
- Miglitol
- Mineral Oil
- Minoxidil
- Modafinil
- Mometasone
- Nefazodone
- Nelfinavir
- Nevirapine
- Nilotinib
- Nitroprusside
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ospemifene
- Oxcarbazepine
- Pentobarbital
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Posaconazole
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prednisolone
- Prednisone
- Primidone
- Propoxyphene
- Raloxifene
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Ritonavir
- Rituximab; Hyaluronidase
- Ropinirole
- Saquinavir
- Saxagliptin
- Secobarbital
- Semaglutide
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sincalide
- Sitagliptin
- Sodium Iodide
- Somatropin, rh-GH
- St. John’s Wort, Hypericum perforatum
- Sulfonylureas
- Tacrine
- Tazemetostat
- Testolactone
- Thiazolidinediones
- Thiopental
- Thyroid hormones
- Tipranavir
- Tolazamide
- Tolbutamide
- Topiramate
- Toremifene
- Trandolapril; Verapamil
- Tranexamic Acid
- Trastuzumab; Hyaluronidase
- Triamcinolone
- Tricyclic antidepressants
- Ulipristal
- Ursodeoxycholic Acid, Ursodiol
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast
