Doripenem Brand Name– Doribax
What is Doripenem
Doripenem is an intravenous synthetic carbapenem antimicrobial agent. It is similar in structure and activity to meropenem and, like meropenem, it does not require concomitant administration of a renal enzyme inhibitor (e.g., cilastatin).
Doripenem has good activity against both gram-positive and gram-negative bacteria.
It appears to have superior in vitro activity against Pseudomonas aeruginosa compared to imipenem and meropenem. It is stable against most beta-lactamases and is effective at low doses.
Doripenem was approved by the FDA for treatment of complicated urinary tract infection, including pyelonephritis and complicated intra-abdominal infections on October 12, 2007. It is also under investigation for treating nosocomial pneumonia; the NDA was submitted in June 2007.
Indications
- Acinetobacter baumannii
- bacteremia
- Bacteroides caccae
- Bacteroides fragilis
- Bacteroides thetaiotaomicron
- Bacteroides uniformis
- Bacteroides vulgatus
- Citrobacter freundii
- Enterobacter cloacae
- Escherichia coli
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Morganella morganii
- Peptostreptococcus micros
- Proteus mirabilis
- Pseudomonas aeruginosa
- pyelonephritis
- sepsis
- Serratia marcescens
- Staphylococcus aureus (MSSA)
- Streptococcus agalactiae (group B streptococci)
- Streptococcus constellatus
- Streptococcus intermedius
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- urinary tract infection (UTI)
Side Effects
- anaphylactoid reactions
- anemia
- candidiasis
- diarrhea
- elevated hepatic enzymes
- headache
- leukopenia
- nausea
- neutropenia
- phlebitis
- pneumonitis
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- seizures
- Stevens-Johnson syndrome
- thrombocytopenia
- toxic epidermal necrolysis
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- administration via nebulizer
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- children
- colitis
- diarrhea
- geriatric
- GI disease
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal impairment
- respiratory infection
- seizure disorder
- stroke
- ulcerative colitis
- viral infection
Interactions
- Colchicine; Probenecid
- Oral Contraceptives
- Probenecid
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Valproic Acid, Divalproex Sodium
- Warfarin
