Difluprednate Brand Name– Durezol
What is Difluprednate
Difluprednate (Durezol) is an ophthalmic steroid emulsion.
It is FDA-approved for the treatment for postoperative ocular pain and inflammation and endogenous anterior uveitis.
Difluprednate rapidly penetrates the cornea, resulting in a quick decrease in anterior chamber cell count and resolution of flare. In clinical trials, difluprednate showed a rapid resolution of ocular inflammation versus placebo with few treatment related adverse events.
The safety and efficacy of difluprednate dosed four times a day was comparable to betamethasone ophthalmic solution 0.1% in post-operative and uveitis studies.
Durezol was approved by the FDA in June 2008.
Indications
- ocular pain
- postoperative ocular inflammation
- uveitis
For the treatment of postoperative ocular pain and postoperative ocular inflammation
Side Effects
- blepharitis
- blurred vision
- cataracts
- conjunctival hyperemia
- corneal edema
- foreign body sensation
- hyperemia
- impaired wound healing
- iritis
- keratitis
- lacrimation
- macular edema
- ocular hypertension
- ocular infection
- ocular inflammation
- ocular irritation
- ocular pain
- ocular pruritus
- photophobia
- striae
- superinfection
- uveitis
- visual impairment
- xerophthalmia
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- breast-feeding
- cataracts
- contact lenses
- corneal abrasion
- corticosteroid hypersensitivity
- diabetes mellitus
- fungal infection
- glaucoma
- glycerin hypersensitivity
- herpes simplex keratitis (dendritic keratitis)
- increased intraocular pressure
- mycobacterial infection
- ocular infection
- open-angle glaucoma
- polysorbate 80 hypersensitivity
- pregnancy
- varicella
- viral infection
Interactions
There are no drug interactions associated with Difluprednate products.
