Dichlorphenamide Brand Name– Keveyis
What is Dichlorphenamide
Dichlorphenamide is an oral carbonic anhydrase inhibitor for the treatment of primary hypokalemic or hyperkalemic periodic paralysis and related variants.
Dichlorphenamide may cause hypokalemia and hyperchloremic non-anion gap metabolic acidosis, and the severity may increase with the use of other drugs that cause hypokalemia or metabolic acidosis.
Dichlorphenamide was originally FDA-approved in July 1958.
Indications
- primary hyperkalemic periodic paralysis
- primary hypokalemic periodic paralysis
For the treatment of primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants
Side Effects
- agranulocytosis
- amnesia
- aplastic anemia
- arthralgia
- confusion
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- fatigue
- hallucinations
- headache
- heart failure
- hepatic necrosis
- hypoesthesia
- hypokalemia
- lethargy
- malaise
- metabolic acidosis
- nausea
- nephrolithiasis
- pancytopenia
- paresthesias
- pruritus
- psychosis
- rash
- renal tubular necrosis
- seizures
- Stevens-Johnson syndrome
- syncope
- toxic epidermal necrolysis
- tremor
- weight loss
Monitoring Parameters
- serum bicarbonate
- serum potassium
Contraindications
- aspirin coadministration
- breast-feeding
- carbonic anhydrase inhibitor hypersensitivity
- Cushing’s syndrome
- geriatric
- hepatic disease
- hepatic encephalopathy
- hypokalemia
- labor
- metabolic acidosis
- neonates
- obstetric delivery
- pregnancy
- pulmonary disease
- renal tubular acidosis (RTA)
- respiratory acidosis
- sulfonamide hypersensitivity
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetazolamide
- Aclidinium; Formoterol
- Adefovir
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Allopurinol
- Alogliptin; Metformin
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Ammonium Chloride
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Ampicillin
- Ampicillin; Sulbactam
- Anidulafungin
- Arformoterol
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Basiliximab
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisacodyl
- Budesonide; Formoterol
- Bumetanide
- Calcium Carbonate; Magnesium Hydroxide
- Canagliflozin; Metformin
- Casanthranol; Docusate Sodium
- Caspofungin
- Castor Oil
- Cefaclor
- Ceftizoxime
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Colchicine; Probenecid
- Cyclosporine
- Dapagliflozin; Metformin
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Decitabine
- Deferiprone
- Desflurane
- Dicloxacillin
- Diphenhydramine; Ibuprofen
- Docusate
- Docusate Sodium; Senna
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Epinephrine
- Ertugliflozin; Metformin
- Ethacrynic Acid
- Etoposide, VP-16
- Ezogabine
- Famotidine
- Famotidine; Ibuprofen
- Fidaxomicin
- Fluconazole
- Flucytosine
- Formoterol
- Formoterol; Mometasone
- Furosemide
- Gallium Ga 68 Dotatate
- Ganciclovir
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Griseofulvin
- Hetastarch
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone; Ibuprofen
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ixabepilone
- Ketoconazole
- Lactulose
- Lamivudine; Tenofovir Disoproxil Fumarate
- Leflunomide
- Lesinurad; Allopurinol
- Levalbuterol
- Linagliptin; Metformin
- Lorazepam
- Lubiprostone
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salicylate
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Mannitol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methazolamide
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methotrexate
- Methylcellulose
- Micafungin
- Mineral Oil
- Mycophenolate
- Nafcillin
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Omeprazole; Amoxicillin; Rifabutin
- Oseltamivir
- Oxacillin
- Palonosetron
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Phentermine; Topiramate
- Polyethylene Glycol
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Ponatinib
- Posaconazole
- Potassium Phosphate; Sodium Phosphate
- Prilocaine; Epinephrine
- Probenecid
- Propofol
- Psyllium
- Pyridoxine, Vitamin B6
- Salsalate
- Senna
- Sevelamer
- Sodium benzoate; sodium phenylacetate
- Sodium Phenylbutyrate
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sorbitol
- Spironolactone
- Teniposide
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terbinafine
- Teriflunomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Tigecycline
- Topiramate
- Torsemide
- Triamterene
- Vincristine Liposomal
- Voriconazole
- Zonisamide
