Delafloxacin Brand Name– Baxdela
What is Delafloxacin
Delafloxacin is a fluoroquinolone antibiotic approved in adults for oral or intravenous use in the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired pneumonia (CAP) due to susceptible bacteria.
Disabling and potentially irreversible serious adverse reactions associated with quinolones include tendinitis, tendon rupture, peripheral neuropathy, central nervous system effects, and aortic aneurysm or dissection.
Indications
- Chlamydophila pneumoniae
- community-acquired pneumonia
- Enterobacter cloacae
- Enterococcus faecalis
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Legionella pneumophila
- Moraxella catarrhalis
- Mycoplasma pneumoniae
- pneumonia
- Proteus mirabilis
- Pseudomonas aeruginosa
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus haemolyticus
- Staphylococcus lugdunesis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus dysgalactiae
- Streptococcus intermedius
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- abdominal pain
- agitation
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- aortic dissection
- arthralgia
- arthropathy
- blurred vision
- bradycardia
- candidiasis
- coma
- confusion
- delirium
- depression
- diarrhea
- dizziness
- dysesthesia
- dysgeusia
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- flushing
- hallucinations
- headache
- hyperglycemia
- hypertension
- hypoesthesia
- hypoglycemia
- hypotension
- infection
- infusion-related reactions
- insomnia
- leukopenia
- memory impairment
- myalgia
- myasthenia gravis
- nausea
- neurotoxicity
- neutropenia
- nightmares
- palpitations
- pancytopenia
- paranoia
- paresthesias
- peripheral neuropathy
- pruritus
- pseudomembranous colitis
- psychosis
- rash
- renal failure (unspecified)
- restlessness
- seizures
- sinus tachycardia
- suicidal ideation
- superinfection
- syncope
- tendinitis
- tendon rupture
- tinnitus
- tremor
- urticaria
- vertigo
- vomiting
- weakness
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- aneurysm
- aortic dissection
- arteriosclerosis
- breast-feeding
- cerebrovascular disease
- colitis
- corticosteroid therapy
- diabetes mellitus
- dialysis
- diarrhea
- driving or operating machinery
- geriatric
- GI disease
- hypertension
- inflammatory bowel disease
- myasthenia gravis
- neurotoxicity
- organ transplant
- peripheral neuropathy
- pregnancy
- pseudomembranous colitis
- psychiatric event
- quinolone hypersensitivity
- renal disease
- renal failure
- renal impairment
- seizure disorder
- tendinitis
- tendinopathy
- tendon pain
- tendon rupture
- ulcerative colitis
Interactions
- Acarbose
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetohexamide
- Albiglutide
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amlodipine; Celecoxib
- Azelastine; Fluticasone
- Budesonide
- Budesonide; Formoterol
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Canagliflozin
- Canagliflozin; Metformin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Celecoxib
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Choline Salicylate; Magnesium Salicylate
- Chromium
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Diflunisal
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esomeprazole; Naproxen
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Exenatide
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Incretin Mimetics
- Indomethacin
- Insulin Aspart
- Insulin Aspart; Insulin Aspart Protamine
- Insulin Degludec
- Insulin Degludec; Liraglutide
- Insulin Detemir
- Insulin Glargine
- Insulin Glargine; Lixisenatide
- Insulin Glulisine
- Insulin Lispro
- Insulin Lispro; Insulin Lispro Protamine
- Insulin, Inhaled
- Insulins
- Iron
- Iron Salts
- Isophane Insulin (NPH)
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lente Insulin
- Leuprolide; Norethindrone
- Levonorgestrel
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lixisenatide
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salicylate
- Magnesium Salts
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Meloxicam
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methylprednisolone
- Miglitol
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nonsteroidal antiinflammatory drugs
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Oxaprozin
- Pioglitazone
- Piroxicam
- Polycarbophil
- Polysaccharide-Iron Complex
- Porfimer
- Pramlintide
- Prednisolone
- Prednisone
- Quinapril
- Regular Insulin
- Regular Insulin; Isophane Insulin (NPH)
- Repaglinide
- Rofecoxib
- Rosiglitazone
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Semaglutide
- Sevelamer
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sucralfate
- Sulfonylureas
- Sulindac
- Thiazolidinediones
- Tolazamide
- Tolbutamide
- Tolmetin
- Triamcinolone
- Ultralente Insulin
- Valdecoxib
- Verteporfin
- Zinc
- Zinc Salts
