What's on this Page
Daptomycin Brand Names- Cubicin | Cubicin RF
What is Daptomycin
Daptomycin is an intravenous cyclic lipopeptide antibiotic derived from fermentation of Streptomyces roseosporus.
Lipopeptides have a spectrum of activity similar to vancomycin; daptomycin is the first antibiotic from this class to be studied clinically.
In vitro, daptomycin has been shown to be effective against a broad spectrum of gram-positive organisms.
Daptomycin also demonstrates greater in vitro activity than dalfopristin-quinupristin, linezolid, or vancomycin against some gram-positive bacteria.
Daptomycin is FDA-approved for complicated skin and skin structure infections caused by gram-positive organisms, including both methicillin-susceptible and resistant strains of S. aureus as well as for methicillin-susceptible and resistant S. aureus bloodstream infections, including patients with right-sided infective endocarditis.
Because daptomycin is inactivated by pulmonary surfactant, it is ineffective for treating pneumonia.
Phase 3 clinical trials in community-acquired pneumonia showed reduced efficacy of daptomycin.
Daptomycin is FDA-approved for adults and pediatric patients 1 year of age and older
Indications
- bacteremia
- bone and joint infections
- Corynebacterium jeikeium
- endocarditis
- Enterococcus faecalis
- Enterococcus faecium
- febrile neutropenia
- infectious arthritis
- orthopedic device-related infection
- osteomyelitis
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus haemolyticus
- Streptococcus agalactiae (group B streptococci)
- Streptococcus dysgalactiae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- vancomycin-resistant enterococci (VRE)
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- arthralgia
- atrial fibrillation
- atrial flutter
- blurred vision
- bullous rash
- candidiasis
- cardiac arrest
- chest pain (unspecified)
- cough
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyskinesia
- dysphagia
- dyspnea
- eczema vaccinatum
- edema
- elevated hepatic enzymes
- eosinophilia
- eosinophilic pneumonia
- erythema
- fatigue
- fever
- flushing
- hallucinations
- headache
- hyperhidrosis
- hyperphosphatemia
- hypertension
- hypoesthesia
- hypomagnesemia
- hypoprothrombinemia
- hypotension
- infection
- insomnia
- jaundice
- leukocytosis
- lymphadenopathy
- muscle cramps
- myalgia
- myopathy
- nausea
- ocular irritation
- paresthesias
- peripheral neuropathy
- prolonged bleeding time
- proteinuria
- pruritus
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- rhabdomyolysis
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombocytopenia
- thrombocytosis
- tinnitus
- vaginitis
- vertigo
- vesicular rash
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- CBC with differential
- creatine phosphokinase (CPK)
- serum creatinine/BUN
Contraindications
- breast-feeding
- colitis
- diarrhea
- eosinophilic pneumonia
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- myopathy
- neonates
- peripheral neuropathy
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- rhabdomyolysis
- ulcerative colitis
Interactions
- HMG-CoA reductase inhibitors
- Oral Contraceptives
- Red Yeast Rice
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tobramycin
- Warfarin
