Dacarbazine DTIC

Drugs / By Seekhealthz Editorial

Dacarbazine DTIC Brand Name– DTIC-Dome

What is Dacarbazine DTIC

Dacarbazine is a cell cycle-phase nonspecific antineoplastic drug that is believed to be an alkylating agent.

Dacarbazine is unlike conventional alkylating agents such as cyclophosphamide or chlorambucil.

It is used in the treatment of metastatic malignant melanoma, osteogenic sarcoma, soft-tissue sarcoma, and Hodgkin lymphoma.

Dacarbazine is also referred to in the literature as DTIC, which stands for dimethyl-triazeno-imidazole-carboxamide.

Indications

carcinomatous meningitis
Ewing’s sarcoma
Hodgkin lymphoma
malignant melanoma
neuroblastoma
osteogenic sarcoma
rhabdomyosarcoma
soft-tissue sarcoma

For the treatment of metastatic malignant melanoma

for the single-agent treatment of metastatic melanoma

Side Effects

alopecia
anaphylactoid reactions
anemia
anorexia
bone marrow suppression
diarrhea
elevated hepatic enzymes
erythema
fever
flushing
hepatic necrosis
hepatotoxicity
injection site reaction
leukopenia
malaise
myalgia
nausea
neutropenia
new primary malignancy
paresthesias
photosensitivity
thrombocytopenia
thrombosis
tissue necrosis
urticaria
vomiting

Monitoring Parameters

CBC
LFTs
serum creatinine/BUN

Contraindications

accidental exposure
bone marrow suppression
breast-feeding
dacarbazine (DTIC) hypersensitivity
dental disease
dental work
extravasation
hepatic disease
hepatic necrosis
hepatotoxicity
herpes infection
infection
intramuscular administration
intramuscular injections
neutropenia
new primary malignancy
ocular exposure
pregnancy
radiation therapy
renal impairment
requires an experienced clinician
subcutaneous administration
thrombocytopenia
vaccination
varicella
viral infection

Interactions

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