Carboprost Tromethamine

Sharing is caring!

Carboprost Tromethamine Brand Name– Hemabate

What is Carboprost Tromethamine

Carboprost tromethamine is the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2-alpha.

Clinically, carboprost tromethamine, an oxytocic, is used as a treatment for refractory postpartum uterine bleeding and as an abortifacient in gestation weeks 13 to 20 or in the second trimester under specific conditions.

Comparative data for abortion are available for another FDA-approved prostaglandin analogue, dinoprostone.

Among pregnant women of 14—24 weeks gestation, the cumulative abortion rate after 24 hours of drug receipt was 96% with dinoprostone 20 mg intravaginal suppositories and was 69% with carboprost 250 mcg IM; 8 patients who got carboprost as compared with 1 patient who got dinoprostone delivered after 24 hours of drug receipt.

The mean times to delivery of the fetus and of the placenta were significantly shorter with dinoprostone, but carboprost is recommended to be given every 1.5—3 hours whereas dinoprostone is given every 3—5 hours; in the study, both drugs were given every 3 hours until delivery.

Treatment selection is highly physician specific; consider medical history of patient, gestational age of fetus, and the availability of emergency medical and follow-up care.

The high incidence of transient gastrointestinal adverse events, the possibility of incomplete expulsion of uterine contents, and patient disfavor of IM administration may limit carboprost tromethamine use. Sales of carboprost are restricted to hospitals only.

Carboprost was approved by the FDA in 1979.

Indications

  1. hemorrhagic cystitis
  2. postpartum bleeding
  3. pregnancy termination

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angioedema
  5. anxiety
  6. back pain
  7. blurred vision
  8. bronchospasm
  9. cervical laceration
  10. chest pain (unspecified)
  11. chills
  12. cough
  13. diaphoresis
  14. diarrhea
  15. dizziness
  16. drowsiness
  17. dysmenorrhea
  18. dyspnea
  19. dystonic reaction
  20. epistaxis
  21. fever
  22. flushing
  23. headache
  24. hematemesis
  25. hot flashes
  26. hypertension
  27. hyperventilation
  28. injection site reaction
  29. insomnia
  30. lethargy
  31. mastalgia
  32. muscle cramps
  33. musculoskeletal pain
  34. nausea
  35. ocular pain
  36. palpitations
  37. paresthesias
  38. pulmonary edema
  39. rash
  40. shivering
  41. sinus tachycardia
  42. syncope
  43. thyrotoxicosis
  44. tinnitus
  45. torticollis
  46. uterine rupture
  47. vertigo
  48. vomiting
  49. weakness
  50. wheezing
  51. xerostomia

Monitoring Parameters

  • pelvic exam
  • pregnancy testing

Contraindications

  • anemia
  • asthma
  • benzyl alcohol hypersensitivity
  • breast-feeding
  • caesarean section
  • cardiac disease
  • children
  • chorioamnionitis
  • diabetes mellitus
  • hepatic disease
  • hypertension
  • hypotension
  • incomplete abortion
  • infants
  • infection
  • jaundice
  • neonates
  • pregnancy
  • pulmonary disease
  • renal disease
  • seizure disorder
  • surgery
  • trauma

Interactions

  • Dinoprostone, Prostaglandin E2
  • Ergonovine
  • Methylergonovine
  • Oxytocin

Sharing is caring!

You cannot copy content of this page

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top