Bosutinib Brand Name– BOSULIF
What is Bosutinib
Bosutinib is an oral multi-tyrosine kinase inhibitor that works by inhibiting Bcr-Abl and Src family kinases.
Bosutinib is indicated for the treatment of adult patients with newly diagnosed chronic phase (CP) Philadelphia chromosome-positive (Ph+ CML) and CP, accelerated phase (AP), or blast phase (BP) Ph+ CML with resistance or intolerance to prior therapy.
Serious adverse reactions reported with bosutinib use include anaphylactic shock, myelosuppression, gastrointestinal toxicity, fluid retention, and hepatotoxicity.
Indications
- chronic myelogenous leukemia (CML)
For the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML)
NOTE: The FDA has designated bosutinib as an orphan drug for the treatment of CML.
Side Effects
- abdominal pain
- acne vulgaris
- acneiform rash
- anaphylactic shock
- anemia
- anorexia
- arthralgia
- asthenia
- back pain
- chest pain (unspecified)
- contact dermatitis
- cough
- dehydration
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyspnea
- edema
- elevated hepatic enzymes
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- fluid retention
- gastritis
- GI bleeding
- headache
- heart failure
- hepatitis
- hyperamylasemia
- hyperbilirubinemia
- hyperkalemia
- hypertension
- hypophosphatemia
- infection
- influenza
- leukopenia
- maculopapular rash
- malaise
- myalgia
- nausea
- nephrotoxicity
- neutropenia
- pancreatitis
- pericardial effusion
- pericarditis
- peripheral edema
- pharyngitis
- photosensitivity
- pleural effusion
- pruritus
- pulmonary edema
- pulmonary hypertension
- QT prolongation
- rash
- renal failure (unspecified)
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombotic microangiopathy
- tinnitus
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- serum creatinine/BUN
Contraindications
- abdominal pain
- anemia
- breast-feeding
- contraception requirements
- diarrhea
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- infertility
- nausea/vomiting
- nephrotoxicity
- neutropenia
- pericardial effusion
- peripheral edema
- pleural effusion
- pregnancy
- pregnancy testing
- pulmonary edema
- renal disease
- renal failure
- renal impairment
- reproductive risk
- thrombocytopenia
- ventricular dysfunction
Interactions
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Boceprevir
- Brigatinib
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbamazepine
- Ceritinib
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clozapine
- Cobicistat
- Conivaptan
- Crizotinib
- Dabigatran
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dexlansoprazole
- Diltiazem
- Doxorubicin
- Duvelisib
- Edoxaban
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Encorafenib
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole
- Esomeprazole; Naproxen
- Famotidine
- Famotidine; Ibuprofen
- Fedratinib
- Fluconazole
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- H2-blockers
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lansoprazole
- Lansoprazole; Naproxen
- Lefamulin
- Letermovir
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Magnesium Hydroxide
- Mitotane
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nizatidine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Pantoprazole
- Phenobarbital
- Phenytoin
- Posaconazole
- Rabeprazole
- Ranitidine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rifaximin
- Ritonavir
- Rivaroxaban
- Saquinavir
- Simeprevir
- Sodium Bicarbonate
- St. John’s Wort, Hypericum perforatum
- Telaprevir
- Telithromycin
- Ticagrelor
- Trandolapril; Verapamil
- Verapamil
- Vincristine
- Vincristine Liposomal
- Voriconazole
