Auranofin Brand Name– Ridaura
What is Auranofin
Auranofin is a disease-modifying antirheumatic drug (DMARD) used to treat early active cases of rheumatoid arthritis (RA) and is the only gold compound available for oral administration.
Auranofin is less effective against advanced, chronic cases of RA, as it does not reverse prior structural deformities from the disease.
Initiation of a DMARD within 3 months of RA diagnosis is recommended.
Periodic assessment of disease activity is advised; auranofin usually requires 3—6 months to achieve full therapeutic response.
If ongoing, active disease is present after 3 months of maximal therapy, addition of another DMARD or initiation of a different DMARD is recommended in methotrexate-naive patients.
Addition of another DMARD, initiation of a different DMARD, or initiation of a biologic is recommended for patients with a suboptimal response to methotrexate.
Indications
- rheumatoid arthritis
For the treatment of active rheumatoid arthritis in patients who have had an insufficient therapeutic response to or are intolerant of an adequate trial of full doses of at least one nonsteroidal anti-inflammatory drug
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anemia
- angioedema
- anorexia
- aplastic anemia
- azotemia
- bleeding
- bullous rash
- chest pain (unspecified)
- cholestasis
- colitis
- conjunctivitis
- constipation
- cough
- diaphoresis
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- ecchymosis
- elevated hepatic enzymes
- enterocolitis
- eosinophilia
- exfoliative dermatitis
- fever
- flatulence
- flushing
- GI bleeding
- gingivitis
- glomerulonephritis
- glossitis
- gold toxicity
- hematuria
- hypotension
- interstitial nephritis
- jaundice
- leukopenia
- maculopapular rash
- melena
- metallic taste
- nausea
- nephrotic syndrome
- nephrotoxicity
- neutropenia
- neutropenia
- oral ulceration
- palpitations
- pancytopenia
- peripheral neuropathy
- petechiae
- pneumonitis
- proteinuria
- pruritus
- pulmonary fibrosis
- purpura
- rash
- red cell aplasia
- sinus tachycardia
- skin discoloration
- stomatitis
- syncope
- thrombocytopenia
- urticaria
- vomiting
- weakness
- wheezing
Monitoring Parameters
- CBC with differential
- LFTs
- urinalysis
Contraindications
- agranulocytosis
- anemia
- benzyl alcohol hypersensitivity
- bleeding
- bone marrow suppression
- breast-feeding
- children
- diarrhea
- exfoliative dermatitis
- gold toxicity
- hematological disease
- hematuria
- hepatic disease
- infants
- inflammatory bowel disease
- lactase deficiency
- leukopenia
- necrotizing enterocolitis
- neutropenia
- pregnancy
- proteinuria
- pulmonary fibrosis
- renal disease
- renal failure
- renal impairment
- requires an experienced clinician
- serious rash
- stomatitis
- sunlight (UV) exposure
- thrombocytopenia
Interactions
- Amikacin
- Aminoglycosides
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Angiotensin-converting enzyme inhibitors
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Celecoxib
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Dimercaprol
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gentamicin
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Kanamycin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lisinopril
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Moexipril
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Paromomycin
- Penicillamine
- Perindopril
- Perindopril; Amlodipine
- Pexidartinib
- Phenytoin
- Piroxicam
- Plazomicin
- Quinapril
- Ramipril
- Riluzole
- Rituximab
- Rituximab; Hyaluronidase
- Rofecoxib
- Streptomycin
- Sulindac
- Tobramycin
- Tolmetin
- Trandolapril
- Trandolapril; Verapamil
- Valdecoxib
- Vancomycin
