Are prophylactic antibiotics appropriate during immunosuppressive treatment?
Oral trimethoprim/sulfamethoxazole (one double-strength tablet thrice a week) provides prophylaxis against P. jiroveci in patients with vasculitis who are receiving high-dose (>15–20 mg/day prednisone) glucocorticoid (GC) therapy. This antibiotic therapy also limits recurrent sinus infections, which can cause exacerbations of GPA. Patients allergic to sulfa can receive dapsone, atovaquone, or inhaled pentamidine.
