Alclometasone Brand Name– Aclovate
What is Alclometasone
Alclometasone is a topical low-to-medium potency synthetic corticosteroid. It is used to relieve the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Low-potency topical corticosteroids have modest antiinflammatory properties and are usually effective in treating acute inflammatory conditions involving areas of thin skin.
Since the stratum corneum is thin on the face and intertriginous areas, low-potency topical corticosteroids are preferred. Low potency topical corticosteroids are also considered the safest for chronic use and are favored in elderly or pediatric patients.
Alclometasone is equivalent in efficacy to desonide and hydrocortisone.
Alclometasone ointment has been shown to be at least as effective as hydrocortisone 1% for the treatment of eczema in children.
The FDA approved alclometasone in 1982.
Indications
- atopic dermatitis
- contact dermatitis
- dermatitis
- discoid lupus erythematosus
- eczema
- exfoliative dermatitis
- granuloma annulare
- lichen planus
- lichen simplex
- polymorphous light eruption
- pruritus
- psoriasis
- Rhus dermatitis
- seborrheic dermatitis
- xerosis
Side Effects
- acneiform rash
- adrenocortical insufficiency
- cataracts
- contact dermatitis
- Cushing’s syndrome
- erythema
- folliculitis
- glycosuria
- growth inhibition
- headache
- hyperglycemia
- hypertension
- hypertrichosis
- hypothalamic-pituitary-adrenal (HPA) suppression
- impaired wound healing
- increased intracranial pressure
- infection
- maculopapular rash
- miliaria
- ocular hypertension
- papilledema
- pruritus
- pseudotumor cerebri
- purpura
- skin atrophy
- skin hypopigmentation
- skin irritation
- skin ulcer
- striae
- telangiectasia
- tolerance
- visual impairment
- withdrawal
- xerosis
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acne rosacea
- acne vulgaris
- breast-feeding
- children
- corticosteroid hypersensitivity
- Cushing’s syndrome
- diabetes mellitus
- fungal infection
- geriatric
- growth inhibition
- herpes infection
- hypothalamic-pituitary-adrenal (HPA) suppression
- increased intracranial pressure
- infants
- infection
- measles
- neonates
- occlusive dressing
- ocular exposure
- perioral dermatitis
- pregnancy
- skin abrasion
- skin atrophy
- tuberculosis
- varicella
- viral infection
Interactions
- Deferasirox
- Metyrapone
