Kidney disease and hypertension in pregnancy 1. Normal pregnancy is associated with decreased serum creatinine and respiratory alkalosis, causing a decrease in serum bicarbonate. 2. The pathogenesis of preeclampsia is thought to be the consequence of the abnormal development of uterine spiral arteries and placental ischemia leading to increased levels of antiangiogenic factors and low levels of …
How to distinguish among different causes of acute kidney injury in pregnancy? Causes of acute kidney injury in Pregnancy HUS HELLP Lupus Nephritis AFLP Cortical Necrosis Creatinine or nl or nl or nl Platelets or nl or nl nl Transaminases nl ↑ nl nl LDH nl nl PT/PTT nl or nl nl nl Schistocytes † …
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How does pregnancy affect nephrolithiasis? Nephrolithiasis is the most common nonobstetric cause of abdominal pain during pregnancy. Pregnancy is characterized by factors that promote (increased urinary calcium and uric acid, decreased peristalsis of the ureter, and dilatation of the collecting system) and prevent (increased urinary magnesium, citrate, and acid glycoproteins) stone formation. Stones may be …
What is diabetes insipidus of pregnancy? Diabetes insipidus of pregnancy is a rare disorder that occurs in the third trimester and resolves within a few weeks postpartum. It is characterized by polyuria, polydipsia, and, if inadequate free water is provided, hypernatremia. It is resistant to exogenous vasopressin and vasopressin levels may be normal or high. …
What are the indications for and risks of kidney biopsy during pregnancy? Indications for kidney biopsy during pregnancy include newly diagnosed lupus, unexplained acute kidney injury, and nephrotic syndrome severe enough to require treatment. In most cases, biopsy can be postponed until the postpartum period. Because of the increased kidney blood flow associated with pregnancy, …
What is the effect of lupus nephritis on pregnancy and vice versa? Lupus occurs most frequently in women of child-bearing age and may be diagnosed during pregnancy. When the onset of lupus nephritis occurs during pregnancy, the kidney histology is often World Health Organization (WHO) class IV, which requires prompt treatment. New-onset lupus is one …
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Can a woman with a kidney transplant become pregnant? Fertility is usually restored by kidney transplant. Three broad areas of concern are: • The effect of pregnancy on the kidney allograft. • The effect of immunosuppressive medication on the fetus. • The risk of opportunistic infection. Women are advised to wait a year after transplant, and to only …
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