Paroxysmal Extreme Pain Disorder
Paroxysmal Extreme Pain Disorder Paroxysmal extreme pain disorder is an uncommon cause of severe, episodic, burning rectal, perineal, ocular, and mandibular pain. Also known as familial rectal pain syndrome, paroxysmal extreme pain disorder is caused by autosomal dominant abnormalities in the voltage-gated sodium channel Na V 1.7 that are induced by mutations of the gene SCN9A. These mutations cause impairment …