Health

Beals syndrome Autosomal dominant disorder of the connective tissue caused by heterozygous pathogenic variants of FBN2 (fibrillin 2)  Patients with congenital contractural arachnodactyly present with a marfanoid physique (eg, tall and slender body in which arm span exceeds height; arachnodactyly; progressive kyphoscoliosis) and cardiac valvular abnormalities; mild aortic dilation is rarely present  Differentiate from Marfan syndrome by …

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8 Interesting Facts of Mammal bites Mammal bites injuries can range in severity from minor superficial contusions, abrasions, or lacerations to severe crushing or tearing injuries with damage to deep structures Type and degree of injury reflect tooth anatomy and jaw strength of biting animal, ferocity of attack, and anatomic location of injury Evaluation includes …

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Malignant hyperthermia (MH) is a life-threatening reaction that is triggered by common medicines used during surgery. MH causes: A sudden increase in the body’s metabolism. High fever. A rapid and irregular heart rate. When these reactions happen, a person may be at risk for severe complications, such as a heart attack, brain damage, internal bleeding, …

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Malaise and fatigue Synopsis Key Points Fatigue comprises the subjective, self-reported symptoms of tiredness, exhaustion, lack of energy, and weariness; malaise is a subjective sense of being unwell Many underlying causes exist, falling into broad categories that include chronic medical disease, psychiatric disease, lifestyle factors, medications, and treatment effects Focus of evaluation for fatigue is …

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Laboratory evaluation for fatigue CBC  Decreased hemoglobin or hematocrit values indicating anemia could explain fatigue, requiring further evaluation for underlying causes Pancytopenia is concerning for hematologic malignancy but could also be due to nutritional deficits or sequelae of viral illnesses Serum chemistry panel Abnormalities in electrolyte levels, glucose level, or liver or renal function test …

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Macrocytic anemia Interesting Facts Macrocytic anemia is a hemoglobin level below reference range with mean corpuscular volume greater than 100 fL  Megaloblastic macrocytic anemias are caused by impaired DNA synthesis and are recognizable by the appearance of large, oval RBCs and hypersegmented neutrophils on peripheral blood smear; other cytopenias may also be present Most common …

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What is the differential diagnosis for dense metaphyseal bands, and how to know when they are abnormally dense? Dense metaphyseal bands, also known as metaphyseal dysplasia, can be seen on imaging studies such as X-rays and may be associated with various conditions. The presence of dense metaphyseal bands alone is not specific to a particular …

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