Are there any other peripheral neuropathies? Yes—there are many. More examples include hereditary sensory neuropathy type I (a rare autosomal dominant disorder), painful polyneuropathy associated with Guillan-Barre syndrome (an acute myelinopathy), or chronic inflammatory demyelinating polyneuropathy (a chronic myelinopathy), as well as neuropathies related to porphyria and autoimmune disorders. Sensorimotor neuropathies may present as part …
What are some less common peripheral neuropathies? There are many other peripheral neuropathies. Hypothyroidism can cause a sensory polyneuropathy as well as mononeuropathy due to entrapment (most commonly carpal tunnel syndrome). Uremia and chronic renal failure are associated with a sensory polyneuropathy. Amyloidosis is associated with pain, small-fiber dysfunction (e.g., loss of pain and thermal senses), and …
Chemotherapy induced peripheral neuropathies Chemotherapy drugs are known to most commonly cause a sensory neuropathy in a “stocking and glove” distribution known as chemotherapy-induced peripheral neuropathy (CIDP). This effect is dose dependent and cumulative. Cisplatin, oxaliplatin, paclitaxel (can also be associated with a motor neuropathy), vincristine, and thalidomide have all been implicated in chronic neurotoxicity. …
human immunodeficiency virus associated neuropathy HIV infection itself is associated with multiple neuropathic syndromes (30% to 67% of patients), including axonal as well as acute and chronic demyelinating neuropathies, with distal, symmetric polyneuropathy being most common. Between 30% and 67% of HIV patients will develop a neuropathy. CD4 count and HIV viral load were previously …
Diabetic peripheral neuropathy DPN most commonly presents as a distal, symmetric polyneuropathy. Typically feet are predominately effected (stocking distribution) and involvement of the hands comes later (stocking glove distribution). Duration and severity of hyperglycemia are major risk factors, as well as dyslipidemia, hypertension, and smoking. A small fraction of those with DPN will develop painful …
What is small fiber peripheral neuropathy? Small fiber peripheral neuropathy (SFPN) is a type of peripheral neuropathy due to damage of small, unmyelinated C fibers and thinly myelinated A-delta fibers that innervate the skin or autonomic system. It can present with paresthesias, dysesthesias, pain, or numbness. Other symptoms include changes in skin color and temperature, …
Diagnostic tools that may aid in diagnosis of neuropathic pain Electrodiagnostic studies like electromyogram (EMG) and nerve conduction studies can sometimes be helpful in confirming existence of a neurologic lesion. Some patients may dislike these tests, as they require many tiny needle electrodes to be placed, often in painful areas. Thermography, quantitative sensory testing (QST), …
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