7 Interesting Facts of Anaphylaxis Anaphylaxis is a life-threatening systemic or hypersensitivity reaction with sudden onset Signs and symptoms typically start minutes to hours after exposure to a trigger Rapid assessment and early treatment with intramuscular epinephrine is critical Causes can include virtually any agent capable of directly or indirectly activating mast cells or basophils …
Anemia management with chronic kidney disease comorbidity Anemia is hemoglobin level less than 12 g/dL in adult females and less than 13 g/dL in adult males Chronic kidney disease is abnormality in kidney structure or function present for longer than 3 months that affects health Estimated GFR less than 60 mL/minute/1.73m2 indicates decreased function The most …
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Inflammatory Anemia – Anemia of chronic disease (ACD) Inflammatory anemia, also known as anemia of chronic disease (ACD), is a disorder of iron homeostasis promoted by hepcidin-25 in response to an inflammatory condition. Suspected Causes of Anemia of Chronic Disease From Hoffman R et al: Hematology, basic principles and practice, ed 7, Philadelphia, 2018, Elsevier. Shortened erythrocyte survival Block …
Pernicious Anemia Pernicious anemia (PA) is an autoimmune disease resulting from antibodies against gastric intrinsic factor and gastric parietal cells. Synonyms Megaloblastic anemia resulting from vitamin B12 deficiency Addison-Biermer anemia Epidemiology & Demographics •Increased incidence in females and older adults (40 to 70 yr) •More frequent in patients of northern European ancestry •Overall prevalence of undiagnosed …
Sideroblastic Anemia Sideroblastic anemias (SAs) are a heterogeneous group of blood disorders characterized by ring sideroblasts in the bone marrow (abnormal erythroblasts with pathologic iron deposits in the mitochondria distributed in a “ringlike” fashion around the nucleus) and impaired heme biosynthesis. Classification •Congenital sideroblastic anemia (CSA) •Acquired clonal sideroblastic anemia (ACSA) •Acquired reversible sideroblastic anemia …
6 Interesting Facts of Aneurysmal Bone Cyst Aneurysmal bone cyst is a rare, locally destructive, benign skeletal tumor usually involving the metaphysis of long bones in children and young adults Any bone may be involved; most common locations include proximal humerus, distal femur, proximal tibia, and spine Presents with pain and tenderness at site of …
Angiosarcoma Summary 4 Interesting Facts of Angiosarcoma Angiosarcoma (AS) is a malignant vascular tumor derived from endothelial cells. Although its cause is not fully understood, chronic lymphedema and radiation therapy are implicated in some cases. The diagnosis of AS requires a high index of suspicion, and early lesions may be misinterpreted as a bruise or …