Plerixafor Brand Name– Mozobil What is Plerixafor Plerixafor is a novel therapeutic agent used for the mobilization of hematopoietic stem cells (HSC) for subsequent autologous transplantation. It is an inhibitor of the CXCR4 chemokine receptor and blocks binding of its cognate ligand, stromal-cell-derived factor-1-alpha (SDF-1a). CXCR4 and SDF-1a play a role in the trafficking and …
What is Pleconaril Pleconaril (formerly known as VP-63843) is an oral antiviral agent active against a broad spectrum of picornaviruses. Within the genus of Picornaviridae are the enteroviridae (with 71 serotypes) and rhinoviridae (with > 100 serotypes). Rhinoviruses lead to the common cold, most common in the fall and spring, and have been implicated in …
Plecanatide Brand Name– TRULANCE What is Plecanatide Plecanatide is a guanylate cyclase-C agonist approved for adults for treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). In 2 randomized, 12-week studies of more than 2,600 patients with CIC, plecanatide-treated patients achieved the primary endpoint of significantly greater efficacy responder rates compared …
Plazomicin Brand Name– ZEMDRI What is Plazomicin Plazomicin is a parenteral aminoglycoside antibiotic indicated for complicated urinary tract infections (cUTI), including pyelonephritis, caused by certain Enterobacteriaceae in adults. Due to limited safety and efficacy data, reserve plazomicin use for patients who have limited or no alternative treatment options. Plazomicin is not inhibited by most aminoglycoside-modifying …
Pitolisant Brand Name– WAKIX What is Pitolisant Pitolisant is an oral histamine-3 (H3) receptor antagonist/inverse agonist, the first in its class. Pitolisant is indicated for the treatment of excessive daytime sleepiness (EDS) in adult patients with narcolepsy. The efficacy of pitolisant for the treatment of EDS was established in 2 placebo-controlled, active control trials of …
Pitavastatin Brand Names Livalo | NIKITA | Zypitamag What is Pitavastatin Pitavastatin is a member of the HMG-CoA reductase inhibitor (‘statin’) class of lipid-lowering drugs with moderately potent LDL-lowering effects. In patients with primary hypercholesterolemia, doses of 1 mg, 2 mg, and 4 mg PO daily reduce LDL-cholesterol by 32%, 36%, and 43%, respectively; doses of 1 …
Piroxicam Brand Name– Feldene What is Piroxicam Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the enolic acid chemical class. Piroxicam is structurally related to meloxicam, another NSAID. Piroxicam has a long half-life and may be administered as a single daily dose, which can be an advantage over other NSAIDs. Other NSAIDs that can be …