Drugs which induce ANCA vasculitis What drugs have been implicated in inducing ANCA vasculitis? The development of vasculitis with ANCAs has been associated with many agents. The most commonly implicated drug is the anti-thyroid medication, propothiouracil (PTU), with other thyroid agents, including methimazole and carbimazole, also implicated. Other agents reported to be associated with ANCA …
Drugs currently being investigated for treatment of diabetic kidney disease There are multiple other therapies currently being investigated for treatment of diabetic kidney disease. Further studies are needed for all of the following agents before these agents can be recommended for treatment of diabetic kidney disease. Endothelin A Receptor Antagonists The endothelin system plays an …
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Role of ACE inhibitor and ARB in treatment of Diabetic Nephropathy Is there any benefit in using the combination of an ACE inhibitor and an ARB in treatment of DN? Given the significant role of activation of the RAS in the development of DN, many have theorized that combining ACE inhibitors and ARBs would slow …
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Role of immunosuppressive drugs in Membranous Nephropathy The ideal treatment option in patients with primary Membranous Nephropathy remains unclear, and use of immunosuppression is controversial. This is partly due to the variable natural history of the disease and the risks associated with drug toxicity. Immunosuppression is generally reserved for those patients with deteriorating kidney function …
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How effective are lipid lowering drugs in patients with Membranous Nephropathy? Lipid abnormalities associated with proteinuria are likely important players in the high cardiovascular risk seen in patients with MN and thus provide an important target for treatment. Statins can improve the lipid profile and reduce cardiovascular morbidity and mortality in patients with chronic kidney …
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Dosing of antigout drugs in adults with CKD Gout is a common inflammatory arthritis disorder in patients with CKD. Although NSAIDs are the drugs of choice for the treatment of acute attack in patients with normal kidney function, NSAIDs should be avoided or used with caution in patients with CKD. Corticosteroids orally, intravenously, intra-articularly, or …
What are the dosing recommendations for enoxaparin and other low molecular weight heparin in CKD? Enoxaparin dose should be adjusted for the treatment of the most common thrombotic disorders in patient with CKD. For patients with stable estimated GFR less than 30 mL/min, the dose should be adjusted to 1 mg/kg per day and Xa …
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