Drugs

Is combination therapy better than monotherapy for Hypertension? Meta-analyses have suggested that, for most antihypertensive drug classes, combining two different classes of drugs at moderate doses is more likely to lower BP than pushing any one drug to its maximum dose. This also reduces adverse effects. Combining a CCB with an ACE inhibitor, or probably …

Is combination therapy better than monotherapy for Hypertension Read More »

Monotherapy for hypertension Only a minority of patients with hypertension reach their BP targets using only a single drug, so most patients require multiple drugs. Several influential hypertension treatment guidelines have converged on four drug classes as preferred initial therapy, with some exceptions for patients with certain characteristics. In order of their historical introduction, they …

Monotherapy for hypertension Read More »

When is pharmacologic treatment of hypertension indicated? When an individual’s blood pressure (BP) does not fall below goal after a suitable period of intensive lifestyle modifications, antihypertensive drug therapy is universally recommended. There is general agreement that antihypertensive drug therapy is one of the major reasons for the decline in stroke and coronary heart disease …

When is pharmacologic treatment of hypertension indicated Read More »

Drugs contraindicated in hypertensive emergencies Are there some drugs that should not be used to treat hypertensive emergencies? Generally drugs that can cause precipitous hypotension and cannot be recalled or stopped should be avoided. Nifedipine capsules once were widely used for hypertensive urgencies and even emergencies, but the US Food and Drug Administration did not …

Drugs contraindicated in hypertensive emergencies Read More »

What drugs are used for treatment of hypertensive emergencies? Fortunately, many drugs are available, each with their own advantages and disadvantages. Nitroprusside is the most widely available, has the shortest time to effect, and can be easily titrated up or down as needed. It breaks down to cyanide and thiocyanate, which can cause metabolic acidosis, …

What drugs are used for treatment of hypertensive emergencies Read More »

Combination medications for Resistant hypertension Are there any particular recommended drug treatment add ons or combination regimens for Resistant hypertension? The PATHWAY-2 trial showed spironolactone to be the best choice as the fourth-line drug, except in those whose renin level is extremely elevated. In patients with CKD, there is concern regarding hyperkalemia. In CKD stages …

Combination medications for Resistant hypertension Read More »

Antihypertensive Medications for Drug Induced Hypertension What are the usual and customary antihypertensive treatment strategies for patients who have drug induced hypertension? Antihypertensive Treatments for Drug Induced Hypertension DRUGS THAT INDUCE HYPERTENSION ANTIHYPERTENSIVE DRUG TREATMENT(S) Corticosteroids, mineralocorticoids Angiotensin-converting enzyme inhibitor, diuretic Nonsteroidal antiinflammatory drug Diuretic, calcium antagonist, maybe alpha-1-blocker Phenylpropanolamine(s) Beta-blocker Nasal decongestant(s) Alpha-1-blocker or …

Antihypertensive Medications for Drug Induced Hypertension Read More »