Medications for Early Osteo Arthritis What medications have been investigated for use in Early Osteo Arthritis? Multiple therapies have been used to control symptoms in patients with EOA. Topical and oral NSAIDs are typically tried first. Intraarticular steroid injections have proven effective in some patients. Because of the synovial inflammation resembling RA as well as …
Nonbiologic immunosuppressive drugs to treat CTD and their potential malignancies A list of immunosuppressive drugs/agents used in the treatment of connective tissue diseases and their potential malignancies is presented in the below table Immunosuppressive Drugs/Agents Used in the Treatment of CTD and Their Potential Malignancies Treatment Malignancies Hydroxychloroquine None Sulfasalazine None Methotrexate Small risk for …
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What medications used to treat hyperthyroidism can cause rheumatic syndromes? • Propylthiouracil—can cause a systemic vasculitis (perinuclear antineutrophil cytoplasmic antibody [ANCA]-positive) and/or drug-induced lupus syndrome. Similar to other drug-induced autoimmune syndromes, the prevalence of autoantibodies is substantially higher than development of clinical signs of autoimmunity. • Methimazole—can cause a lupus-like syndrome. ANCA antibodies can develop in 10% …
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How the risk of Gout flares due to ULT be minimized Gout flares can be precipitated with the initiation of ULT. How can this risk be minimized? Antiinflammatory prophylaxis is recommended to mitigate the risk of gout flares precipitated by initiation of ULT and should be initiated concomitantly or prior to ULT. Agents most commonly …
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Drug drug interactions of xanthine oxidase inhibitors What drug drug interactions complicate the use of xanthine oxidase inhibitors? Mercaptopurine (MP) and its prodrug azathioprine are metabolized by xanthine oxidase. Thus, the concomitant use of MP or azathioprine with a xanthine oxidase inhibitor (allopurinol or febuxostat) can lead to increased immunosuppressive drug levels and life-threatening bone …
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How are gout flares treated Treatment options for gout flares Medications most often used to treat gout flares include: nonsteroidal antiinflammatory drugs (NSAIDs, full dose), oral colchicine, or glucocorticoids. Patients experiencing a severe flare (polyarticular or severe pain) may require combination therapy, understanding that the concomitant use of NSAIDs and oral glucocorticoids may be less desirable due …
Drugs that cause hyperuricemia due to decreased renal excretion of urate The mnemonic CAN’T LEAP can be used to remember these drugs: C yclosporine Alcohol Nicotinic acid Thiazides/Tacrolimus Lasix (furosemide) (and other loop diuretics) Ethambutol Aspirin (low dose) Pyrazinamide Other drugs that can cause hyperuricemia include levodopa, theophylline, and didanosine. In contrast, the following commonly used drugs exert …