Agalsidase Beta Brand Name– Fabrazyme What is Agalsidase Beta Agalsidase beta (Fabrazyme®) is a recombinant human a-galactosidase A enzyme that is given by intravenous infusion. Patients with Fabry disease have a deficiency of the lysosomal enzyme, ceramidetrihexosidase or a-galactosidase A, which breaks down glycosphingolipids (predominantly globotriaosylceramide or GL-3). Glycosphingolipids accumulate in the lining of blood …
Aflibercept Brand Name– EYLEA What is Aflibercept Aflibercept is a recombinant fusion protein. It binds vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PIGF) and thereby inhibits the binding and activation of these receptors. The drug is approved to treat neovascular (wet) age-related macular degeneration (AMD), macular edema following central retinal vein occlusion (RVO), …
Afatinib Brand Name– GILOTRIF What is Afatinib Afatinib is an oral, selective epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations and in platinum-resistant metastatic NSCLC (not selected for EGFR). Clinically, EGFR expression has been associated with poor prognosis, development of metastasis, …
Afamelanotide Brand Name– SCENESSE What is Afamelanotide Afamelanotide is a melanocortin-1 receptor (MC1-R) agonist approved to increase pain-free light exposure in patients with a history of phototoxic reactions from erythropoietic protoporphyria (EPP). EPP is a rare disorder caused by mutations leading to impaired activity of ferrochelatase, an enzyme involved in heme production. The decrease in …
Ado Trastuzumab emtansine Brand Name– Kadcyla What is Ado Trastuzumab emtansine Ado trastuzumab emtansine is a HER2-targeted antibody-drug conjugate (ADC) that contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug, DM1 (a derivative of maytansine) by a stable thioether linker MCC (4-[N-maleimidomethyl] cyclohexane-1-carboxylate). Emtansine refers to the MCC-DM1 conjugate. It is …
Adenosine Brand Names- Adenocard | Adenoscan What is Adenosine Adenosine, a ubiquitous, endogenous purine nucleotide, is available commercially for use as an antiarrhythmic agent in the management of reentrant paroxysmal supraventricular tachycardias including those associated with Wolff-Parkinson-White (WPW) syndrome. Because of its unique chemical structure, adenosine cannot be categorized as an antiarrhythmic agent using the Vaughn-Williams …
Adefovir Brand Name– Hepsera What is Adefovir Adefovir dipivoxil is an acyclic nucleotide analog approved for the treatment of chronic hepatitis B virus (HBV) infections in patients 12 years and older. The drug is administered once daily; however, the dosing interval must be expanded for patients with renal impairment. Monitor renal function for all patients …