Drugs

Nonpharmacological modalities for pain control

What nonpharmacological modalities can be used for pain control? Given the multifactorial nature of pain, nonpharmacological modalities are often used for the psychological and functional components of the pain experience. Relaxation and biofeedback training are two methods that teach a patient to have a greater sense of awareness of their pain, with the intent to …

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What tools are available to assist prescribers when treating the elderly

What tools are available to assist prescribers when treating the elderly? To help providers minimize the risk of medication-related negative outcomes, multiple screening tools as well as a list of medications with known potential for greater risk than benefit in the elderly have been developed. The Screening Tool of Older People’s Potentially Inappropriate Prescriptions (STOPP) …

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How can side effects related to medications be prevented

How can side effects related to medications be prevented? The elderly population is highly vulnerable to medication-related problems manifesting in adverse events including falls, depression, confusion, constipation, and hip fractures. Studies suggest a 6% to 30% incidence of adverse drug events (ADEs) in the elderly. These ADEs are undesirable, harmful, and in many cases preventable …

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Pharmacokinetic and Pharmacodynamic Changes With Aging

What are the pharmacokinetic and pharmacodynamic changes that occur in the elderly patient? Pharmacokinetic changes are those that affect the absorption, distribution, protein binding, metabolism and bioavailability, and elimination of a drug. Pharmacodynamic changes relate to alterations in drug-receptor interactions. Pharmacokinetic and Pharmacodynamic Changes With Aging and Their Effects CHANGES EFFECT EFFECT ON DRUG USE …

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Physiologic changes that occur in the elderly

What are the physiologic changes that occur in the elderly? CHANGES EFFECT EFFECT ON DRUG USE General Increased body fatDecreased total body waterDecreased muscle mass Increased V d for lipophilic drugsDecreased V d for hydrophilic drugs Lipophilic:Delayed onset of actionProlonged half lifeHydrophilic:Increased plasma levelsHigher frequency of ASEs Cardiovascular Decreased cardiac index Rapid and high drug peak Increased toxicity risk Gastrointestinal Altered …

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