Percentage of patients taking procainamide hydralazine isoniazid or anti TNFα therapy develops a positive ANA

Sharing is caring!

What percentage of patients taking procainamide, hydralazine isoniazid or anti TNFα therapy develops a positive ANA? What percentage of patients develops systemic DILE?

Nearly 75% of patients receiving procainamide therapy will develop a positive ANA test within the first year of treatment, and over 90% develop a positive ANA by 2 years, yet only 20% develop DILE. In contrast, 30% to 50% of patients taking hydralazine will demonstrate a positive test after a year of drug therapy with 5% to 10% developing DILE, especially if they are slow acetylators. Up to 15% of patients on isoniazid develop a positive ANA, but few develop symptoms of DILE. Finally, between 13% and 83% of patients on anti-TNFα therapy develop a positive ANA (most commonly infliximab), but few develop DILE. Therefore, it is important to note that many more patients will demonstrate a positive ANA test than develop DILE, and the presence of a positive ANA test without symptoms is not a valid reason for stopping the medication.

Sharing is caring!

You cannot copy content of this page


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top